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Synthesis and biological evaluation of novel triazole substituted pyrazolyl-methylenehydrazinyl-5-arylidene thiazolidinone derivatives as antibacterial and cytotoxic agents

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Abstract

Novel triazole substituted pyrazolyl-methylenehydrazinyl-5-arylidene thiazolidinone derivatives 6a–n and 7a–l were synthesized and characterized by Fourier transform infrared, 1H and 13C nuclear magnetic resonance, mass spectrometry and elemental (CHN) analysis. The in vitro antibacterial (6a–n and 7a–l) and cytotoxic (6a–n) activities were evaluated for these compounds. The results revealed that the compounds 6b, 6i, 6k, 7b, 7h displayed good antibacterial activity. The compounds 6c (IC50 = 5.4 μM), 6l (IC50 = 6.3 μM) and 6f (IC50 = 9.85 μM) were effective for inhibition of human breast cancer cell line MCF-7. Similarly, the compounds 6b (IC50 = 8.7 μM) and 6c (IC50 = 9.06 μM) were shown to have effective inhibition on human cervical cancer cell line Hela.

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Acknowledgements

S. B. thanks the MHRD, India for the Research Seed Grant (RSG). V. P. thanks the MHRD, India for the fellowship. S.B. and V.P. thank Director, National Institute of Technology Warangal, India for providing research facilities.

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Authors and Affiliations

  1. Department of Chemistry, National Institute of Technology, Warangal, Telangana, 506 004, India

    Vinay Pogaku & Srinivas Basavoju

  2. Department of Biochemistry, Osmania University, Hyderabad, Telangana, 500 007, India

    Ravi Kumar Eslavath & Surya S. Singh

  3. Department of Biotechnology, Kakatiya University, Warangal, Telangana, 506 009, India

    G. Dayakar

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  1. Vinay Pogaku
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  2. Ravi Kumar Eslavath
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  3. G. Dayakar
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Correspondence to Srinivas Basavoju.

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Pogaku, V., Eslavath, R.K., Dayakar, G. et al. Synthesis and biological evaluation of novel triazole substituted pyrazolyl-methylenehydrazinyl-5-arylidene thiazolidinone derivatives as antibacterial and cytotoxic agents. Res Chem Intermed 43, 6079–6098 (2017). https://doi.org/10.1007/s11164-017-2978-4

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