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Synthesis and antibacterial activity of 4,4′-(aryl or alkyl methylene)-bis(1H-pyrazol-5-ol) derivatives

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Abstract

A rapid, improved, and environmentally benign synthesis of 4,4′-aryl or alkyl methylene-bis(1H-pyrazol-5-ols) has been accomplished by tandem Knoevenagel–Michael reaction of 1-aryl-3-alkyl-1H-pyrazol-5-ol with various aldehydes catalyzed by ammonium acetate. All the synthesized compounds 3a–v were evaluated in vitro for their antibacterial activity against Pseudomonas aeruginosa, Xanthomonas protophormiae, Bacillus licheniformis, and Staphylococcus aureus. Among the tested compounds, compounds with trifluromethyl group show excellent antibacterial activity.

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Acknowledgments

Authors are very much thankful to the Director, IICT for his constant encouragement and support and also thankful to UGC for financial assistant.

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Authors and Affiliations

  1. Fluoro Organic Division, Indian Institute of Chemical Technology, Hyderabad, 500 0607, India

    S. Bhavanarushi, V. Kanakaiah & J. Vatsala Rani

  2. Bioengineering and Environmental Engineering Centre (BEEC), Indian Institute of Chemical Technology, Hyderabad, 500 0607, India

    Gandu Bharath & A. Gangagnirao

Authors
  1. S. Bhavanarushi
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  2. V. Kanakaiah
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  3. Gandu Bharath
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  4. A. Gangagnirao
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  5. J. Vatsala Rani
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Correspondence to J. Vatsala Rani.

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Bhavanarushi, S., Kanakaiah, V., Bharath, G. et al. Synthesis and antibacterial activity of 4,4′-(aryl or alkyl methylene)-bis(1H-pyrazol-5-ol) derivatives. Med Chem Res 23, 158–167 (2014). https://doi.org/10.1007/s00044-013-0623-3

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  • DOI: https://doi.org/10.1007/s00044-013-0623-3

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