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Biological potential of pyrimidine derivatives in a new era

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Abstract

Pyrimidine and its derivatives play a wide role in drug discovery processes and have considerable chemical significance and biological activities. Pyrimidines are the building blocks of many natural compounds such as vitamins, liposacharides, and antibiotics. Pyrimidine is used as parent substance for the synthesis of a wide variety of heterocyclic compounds and raw material for drug synthesis and is also crucial in the theoretical development of heterocyclic chemistry and in organic synthesis. Pyrimidine derivatives are vital in several biological activities, i.e. antihypertensive, anticancer, antimicrobial, anti-inflammatory, and antioxidant activity. This creates interest among researchers who have synthesized a variety of pyrimidine derivatives.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India

    Jyoti Rani, Sanjiv Kumar, Monika Saini, Jyoti Mundlia & Prabhakar Kumar Verma

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  1. Jyoti Rani
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  2. Sanjiv Kumar
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  3. Monika Saini
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  4. Jyoti Mundlia
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  5. Prabhakar Kumar Verma
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Correspondence to Prabhakar Kumar Verma.

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Rani, J., Kumar, S., Saini, M. et al. Biological potential of pyrimidine derivatives in a new era. Res Chem Intermed 42, 6777–6804 (2016). https://doi.org/10.1007/s11164-016-2525-8

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