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Synthesis and therapeutic potential of quinoline derivatives

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Abstract

Quinolines are nitrogen-containing bicyclic compounds that are widely found throughout Nature in various forms. Quinoline derivatives are utilized in the areas of medicine, food, catalysts, dyes, materials, refineries, electronics, etc. The quinoline nucleus is present in numerous biological compounds, e.g., antimalarial, antimicrobial, antimycobacterial, antidepressant, anticonvulsant, antiviral, anticancer, antihypertensive, platelet-derived growth factor (PDGF) receptor tyrosine kinase (RTK) inhibitory, antiinflammatory, antioxidant, and anti-human immunodeficiency virus (HIV) agents. However, owing to the swift development of new molecules containing this nucleus, many research reports have been generated in a brief span of time. There therefore seems to be a requirement to collect recent information in order to understand the current status of the quinoline nucleus in medicinal chemistry research, focusing in particular on the numerous attempts to synthesize and investigate new structural prototypes with more effective antimalarial, antimicrobial, and anticancer activity.

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Abbreviations

Candida utilis :

C. utilis

Aspergillus flavus :

A. flavus

Beer yeast:

B. yeast

Candida albicans :

C. albicans

Micrococcus luteus :

M. luteus

Eberthella typhosa :

E. typhosa

Bacillus subtilis :

B. s.

Pseudomonas aeruginosa :

P. a.

Aspergillus clavatus :

A. c.

Methicillin-resistant Staphylococcus aureus :

MRSA

Staphylococcus aureus :

S. aureus

Pseudomonas aeruginosa :

P. aeruginosa

Escherichia coli :

E. coli

Shigella dysenteriae :

S. dysenteriae

Quinolone-resistant S. aureus :

QRSA

Clostridium tetani :

C. t.

Vibrio cholera :

V. c.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India

    Sangeeta Narwal, Sanjiv Kumar & Prabhakar Kumar Verma

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  1. Sangeeta Narwal
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  2. Sanjiv Kumar
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Correspondence to Prabhakar Kumar Verma.

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Narwal, S., Kumar, S. & Verma, P.K. Synthesis and therapeutic potential of quinoline derivatives. Res Chem Intermed 43, 2765–2798 (2017). https://doi.org/10.1007/s11164-016-2794-2

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