Absorption spectra in the region 200 – 400 nm were measured for MeOH, EtOH, and i-PrOH solutions of pharmacologically active 3-phenylrhodanin, a cyclic form of phenethyldithiocarbamoyl acetic acid (cPET). The molar and specific extinction coefficients of cPET in EtOH were determined at 262 and 297 nm. Aprocedure for determining cPET in EtOH by spectrophotometry at 262 nm was developed. The proposed method was characterized by good precision, did not give systematic error, and could be recommended for the determination of cPET in drugs.
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Yu. Ya. Kharitonov, Analytical Chemistry. Analyzer 2 [in Russian], Vysshaya Shkola, Moscow (2010), p. 559.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 1, pp. 54 – 56, January, 2014.
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Novozhilova, N.E., Kutina, N.N. & Kharitonov, Y.Y. Development of a Spectrophotometric Procedure for Determining 3-Phenylrhodanin Drug Substance. Pharm Chem J 48, 69–71 (2014). https://doi.org/10.1007/s11094-014-1049-z
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DOI: https://doi.org/10.1007/s11094-014-1049-z