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Sensitive spectrophotometric method for determination of some phenothiazine drugs

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Abstract

A new simple and sensitive spectrophotometric method for some phenothiazine derivatives has been developed. The proposed method is based on the reaction of phenothiazine derivatives promethazine hydrochloride, chlorpromazine hydrochloride, triflupromazine hydrochloride, prochlorperazine, and trifluoperazine with potassium iodate followed by reaction of liberated iodine with leuco crystal violet (LCV) and measurement of the color of the oxidized LCV at 598 nm. The method showed a good linearity in the ranges 0.05–4.0, 0.02–2.0, 0.05–5.0, 0.1–8.0, and 0.05–2.0 µg mL−1 respectively. The optimum conditions and other analytical parameters were evaluated. The proposed methods have been applied successfully to the analysis of phenothiazine derivatives in pure form and in their dosage forms, and no interference was observed from common excipients present in pharmaceutical formulations.

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Authors and Affiliations

  1. Department of Chemistry, Shri Shankarahcarya Vidyalaya, Aamdi nagar, Hudco, Bhilai, 490006, India

    Kanchan Upadhyay

  2. Department of Chemistry, Govt. V.Y.T.PG. Autonomous College, Durg, India

    Anupama Asthana

  3. Department of Applied Physics, Bhilai Institute of Technology (Seth Balkrishan Memorial), Near Bhilai House, Durg, 491001, C.G., India

    Raunak Kumar Tamrakar

Authors
  1. Kanchan Upadhyay
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  2. Anupama Asthana
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  3. Raunak Kumar Tamrakar
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Correspondence to Kanchan Upadhyay.

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Upadhyay, K., Asthana, A. & Tamrakar, R.K. Sensitive spectrophotometric method for determination of some phenothiazine drugs. Res Chem Intermed 41, 7481–7495 (2015). https://doi.org/10.1007/s11164-014-1838-8

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