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Stem Cells and Natural Agents in the Management of Neurodegenerative Diseases: A New Approach

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A Correction to this article was published on 06 January 2024

This article has been updated

Abstract

Neurodegenerative diseases refer to a group of neurological disorders as a consequence of various destructive illnesses, that predominantly impact neurons in the central nervous system, resulting in impairments in certain brain functions. Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, and other neurodegenerative disorders represent a major risk to human health. In order to optimize structural and functional recovery, reconstructive methods integrate many approaches now, to address the complex and multivariate pathophysiology of neurodegenerative disorders. Stem cells, with their unique property of regeneration, offer new possibilities in regenerative and reconstructive medicine. Concurrently, there is an important role for natural products in controlling many health sufferings and they can delay or even prevent the onset of various diseases. In addition, due to their therapeutic properties, they have been used as neuroprotective agents to treat neurodegenerative disorders. After decades of intensive research, scientists made advances in treating these disorders so far, but current therapies are still not capable of preventing the illnesses from progressing. Therefore, in this review, we focused on a new perspective combining stem cells and natural products as an innovative therapy option in the management of neurodegenerative diseases.

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Data Availability

Enquiries about data availability should be directed to the authors.

Change history

Abbreviations

3-NP:

3-Nitropropionic acid

AD:

Alzheimer’s disease

Aβ:

Amyloid-β

APP:

Amyloid precursor protein

BACE:

APP cleaving enzyme

BDNF:

Brain-derived neurotrophic factor

CNS:

Central nervous system

EAE:

Experimental allergic encephalomyelitis

ESC:

Embryonic stem cell

HD:

Huntington’s disease

hESC:

Human embryonic stem cell

HPA:

Hypothalamic–pituitary–adrenal

HSF:

Heat shock factor

HSP:

Heat shock protein

IFN:

Interferone

IL:

Interleukine

iPSC:

Induced pluripotent stem cell

JNK:

C-Ju N-terminal kinase

MPTP:

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin

MS:

Multiple sclerosis

MSC:

Mesenchymal stem cell

NSC:

Neural stem cell

PD:

Parkinson’s disease

SGZ:

Subgranular zone

SOCS:

Suppressor of cytokine signaling

SVZ:

Subventricular zone

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Authors and Affiliations

  1. Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilians-University Munich, Pettenkoferstrasse 11, 80336, Munich, Germany

    Aranka Brockmueller, Anna-Lena Mueller & Mehdi Shakibaei

  2. Pediatric Urology and Regenerative Medicine Research Center, Gene, Cell and Tissue Research Institute, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Negin Mahmoudi, Amir Kian Movaeni, Abdol-Mohammad Kajbafzadeh & Masoumeh Majidi Zolbin

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  1. Aranka Brockmueller
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  2. Negin Mahmoudi
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  4. Anna-Lena Mueller
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  6. Mehdi Shakibaei
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Contributions

NM, AKM write the primary draft. ALM, AB revised the paper and designed the figures and tables. AMK , MSH and MMZfinal revision of paper and intellectual contribution

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Correspondence to Mehdi Shakibaei or Masoumeh Majidi Zolbin.

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Brockmueller, A., Mahmoudi, N., Movaeni, A.K. et al. Stem Cells and Natural Agents in the Management of Neurodegenerative Diseases: A New Approach. Neurochem Res 48, 39–53 (2023). https://doi.org/10.1007/s11064-022-03746-2

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