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Molecular markers and targeted therapy in pediatric low-grade glioma

  • Topic Review
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Introduction

Recently discovered molecular alterations in pediatric low-grade glioma have helped to refine the classification of these tumors and offered novel targets for therapy. Genetic aberrations may combine with histopathology to offer new insights into glioma classification, gliomagenesis and prognosis. Therapies targeting common genetic aberrations in the MAPK pathway offer a novel mechanism of tumor control that is currently under study.

Methods

We have reviewed common molecular alterations found in pediatric low-grade glioma as well as recent clinical trials of MEK and BRAF inhibitors.

Results

In this topic review, we examine the current understanding of molecular alterations in pediatric low-grade glioma, as well as their role in diagnosis, prognosis and therapy. We summarize current data on the efficacy of targeted therapies in pediatric low-grade gliomas, as well as the many unanswered questions that these new discoveries and therapies raise.

Conclusions

The identification of driver alterations in pediatric low-grade glioma and the development of targeted therapies have opened new therapeutic avenues for patients with low-grade gliomas.

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  1. Department of Pediatrics, University of Cincinnati College of Medicine and the Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA

    Peter de Blank & Maryam Fouladi

  2. Departments of Pathology and Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Jason T. Huse

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All authors contributed to the study conception and design. The first draft of the manuscript was written by PdB and JTH, and MF provided critical revisions of the work. All authors commented on previous versions of the manuscript, and read and approved the final manuscript.

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de Blank, P., Fouladi, M. & Huse, J.T. Molecular markers and targeted therapy in pediatric low-grade glioma. J Neurooncol 150, 5–15 (2020). https://doi.org/10.1007/s11060-020-03529-1

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