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Molecular Profiling and Targeted Therapies in Gliomas

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Abstract

Purpose of Review

Molecular profiling enables the evaluation of genetic alterations for the diagnosis and classification of gliomas and the selection of appropriate therapies. This review summarizes the current role of molecular profiling and targeted therapies for gliomas.

Recent Findings

Molecular profiling is an integral part of the 2021 WHO classification of gliomas. Progress in the development of targeted therapies remains limited due to many factors including the presence of the blood–brain barrier and issues of tumor heterogeneity. Nonetheless, advances have been made with the IDH1/2 inhibitor vorasidenib for IDH-mutant grade 2 gliomas, the combination of dabrafenib and trametinib for BRAFV600E mutated gliomas, and the therapies for subsets of patients with fusions and H3K27M-altered diffuse midline gliomas.

Summary

While there has been progress in the use of molecular profiling for the classification and treatment of gliomas, much work remains for targeted therapies to realize their potential.

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Authors and Affiliations

  1. Neuro-Oncology Division, National Brain Center Hospital, Jakarta, Indonesia

    Yuli Felistia

  2. Center For Neuro-Oncology, Dana-Farber Cancer Institute, Division of Neuro-Oncology, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA

    Patrick Y. Wen

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  1. Yuli Felistia
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  2. Patrick Y. Wen
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Correspondence to Patrick Y. Wen.

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Yuli Felistia declares no potential conflicts of interest. Patrick Y. Wen has received research support from Astra Zeneca, Black Diamond, Bristol Meyers Squibb, Celgene, Chimerix, Eli Lily, Erasca, Genentech/Roche, Kazia, MediciNova, Merck, Novartis, Nuvation Bio, Servier, Vascular Biogenics, and VBI Vaccines (Advisory Board/Consultant: Astra Zeneca, Black Diamond, Celularity, Chimerix, Day One Bio, Genenta, Glaxo Smith Kline, Merck, Mundipharma, Novartis, Novocure, Nuvation Bio, Prelude Therapeutics, Sapience, Servier, Sagimet, VBI Vaccines).

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Felistia, Y., Wen, P.Y. Molecular Profiling and Targeted Therapies in Gliomas. Curr Neurol Neurosci Rep 23, 627–636 (2023). https://doi.org/10.1007/s11910-023-01299-7

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