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Increased histone acetylation levels or a serotonin precursor reinstate the context memory impaired by the serotonin receptor blocker methiothepin

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Abstract

Previously, it was demonstrated that the presumed increase of serotonin (5-HT) release due to the presence of 5-hydroxytryptophan (5-HTP) and changes in histone acetylation levels due to the presence of the histone deacetylase inhibitors sodium butyrate (NaB) and trichostatin A (TSA) reinstate the context memory following its disruption by antimnemonic treatments (protein synthesis blocker anisomycin or a specific inhibitor of protein-kinase Mζ, zeta inhibitory peptide). It is known that a normally functioning serotonergic system is required for successful reconsolidation of context memory in terrestrial snails Helix lucorum. In the present study, we tested possible ways of reinstatement of the context memory after its impairment during reconsolidation with a nonselective antagonist of serotonin receptors methiothepin. We investigated effects of presumed 5-HT increase and histone acetylation increase by injection of the 5-HT precursor 5-HTP or histone deacetylase inhibitors NaB or TSA, correspondingly. It was observed that applications of 5-HTP alone, known to increase the release of 5-HT, or reactivation of memory alone did not restore the methiothepin-impaired context memory, while combination of the 5-HTP + reactivation of memory effectively reinstated the context memory. Additionally, it was observed that the combination of the NaB or TSA plus memory reactivation (reminding or training) was necessary for effective reinstatement of the methiothepin-impaired memory. The data obtained demonstrated that histone deacetylase blockade as well as presumed increase of 5-HT release ameliorated deficits in long-term context memory induced by methiothepin treatment, suggesting that these mechanisms contribute to regulation of the reconsolidation process of context memory.

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Data Availability

The data of the current study are available from the corresponding author on reasonable request.

Abbreviations

5-HT:

Serotonin

5-HTP:

5-Hydroxy-L-tryptophan

CEP:

Cognitive epigenetic priming

HDAC:

Histone deacetylase

HDACi:

Histone deacetylase inhibitor

ITM:

Intermediate memory

LTM:

Long-term memory

MET:

Methiothepin

NaB:

Sodium butyrate

TSA:

Thichostatin A

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Funding

This study was supported by a grant from the Russian Ministry of Education and Science No. 075–15–2020–801.

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  1. Cellular Neurobiology of Learning Lab, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    Alena B. Zuzina & Alia Kh. Vinarskaya

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  1. Alena B. Zuzina
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Correspondence to Alena B. Zuzina.

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All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving snails were in accordance with the ethical standards and approved (#012 from 10.10.2014) by the Ethical Committee of the Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences.

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Zuzina, A.B., Vinarskaya, A.K. Increased histone acetylation levels or a serotonin precursor reinstate the context memory impaired by the serotonin receptor blocker methiothepin. Neurosci Behav Physi 53, 460–472 (2023). https://doi.org/10.1007/s11055-022-01303-6

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