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Histone Deacetylase Inhibitor Prevents Memory Impairment by Methiothepin

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Advances in Cognitive Research, Artificial Intelligence and Neuroinformatics (Intercognsci 2020)

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 1358))

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Abstract

The role of histone acetylation in memory reinstatement after its disruption by antimnemonic drugs has been shown recently. It is known that a normally functioning serotonergic system is required for successful reconsolidation of context memory in terrestrial snails Helix lucorum. In the present study, using the nonselective antagonist of serotonergic receptors methiothepin and the histone deacetylase (HDAC) inhibitor sodium butyrate, we studied the role of histone acetylation in the maintenance and restoration of context memory after its impairment with methiothepin. The results obtained clearly demonstrate that memory impaired by methiothepin during reconsolidation is not restored later under conditions of an increased level of histone acetylation due to administration of sodium butyrate, both with weak memory reactivation (reminder of context) and with strong memory reactivation (electric shock). However, simultaneous administration of HDAC inhibitor sodium butyrate and a blocker of serotonin receptors methiothepin under conditions of memory reactivation prevented the impairment of context memory. The data obtained demonstrated that histone acetylation is a regulatory component for memory maintenance and reconsolidation.

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Abbreviations

5-HT:

Serotonin

HDAC:

Histone deacetylase

MET:

Methiothepin

NaB:

Sodium butyrate

PKMζ:

Protein-kinase Mζ

ZIP:

Zeta Inhibitory Peptide

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Aknowledgments

This study was supported by grant of Russian Science Foundation 19–75-10067 (behavioral experiments), grant of Russian Science Foundation 20–75-00090 (experiments with methiothepin).

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Authors and Affiliations

  1. Cellular Neurobiology of Learning Lab, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    Alena B. Zuzina, Aliya Kh. Vinarskaya, Pavel M. Balaban & Matvey V. Roshchin

Authors
  1. Alena B. Zuzina
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  2. Aliya Kh. Vinarskaya
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  3. Pavel M. Balaban
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  4. Matvey V. Roshchin
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Corresponding author

Correspondence to Alena B. Zuzina .

Editor information

Editors and Affiliations

  1. National Research Center "Kurchatov Institute", Moscow, Russia

    Boris M. Velichkovsky

  2. Institute of Higher Nervous Activity RAS, Moscow, Russia

    Pavel M. Balaban

  3. Institute for Advanced Brain Studies, Lomonosov Moscow State University, Moscow, Russia

    Vadim L. Ushakov

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The authors declare that they have no conflict of interest.

Author Contributions. The authors contributed equally. All authors read and approved the final manuscript.

Ethical Approval: All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving snails were in accordance with the ethical standards and approved (#011 from 10.10.2019) by Ethical Committee of the Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences.

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Zuzina, A.B., Vinarskaya, A.K., Balaban, P.M., Roshchin, M.V. (2021). Histone Deacetylase Inhibitor Prevents Memory Impairment by Methiothepin. In: Velichkovsky, B.M., Balaban, P.M., Ushakov, V.L. (eds) Advances in Cognitive Research, Artificial Intelligence and Neuroinformatics. Intercognsci 2020. Advances in Intelligent Systems and Computing, vol 1358. Springer, Cham. https://doi.org/10.1007/978-3-030-71637-0_71

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