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Eudragit®-based nanoparticles for controlled release through topical use

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Abstract

Eudragit® products are composed of acrylic acid, methacrylic acid, and their esters, which can be used to assemble various drug delivery systems, including polymeric nanoparticles. These nanoparticles make it possible to control the delivery of bioactive molecules (locally and release rate), which is not possible with conventional formulations. In this work, we reviewed the literature to observe the development of nanoparticles for topical application using the different types of Eudragit®. The development of nanoparticles using Eudragit® is known for its reproducible techniques that produce stable and biocompatible particles. The results show that the choice of the polymer was mainly made by the physicochemical properties, looking for polymers that can specifically enhance or avoid the interaction of the nanocarrier with the skin and mucous membranes. Nanoparticles with positive charge and nanometric size interact with physiological membranes to enhance drug efficacy, while particles with negative surface area and pH-dependent release mechanisms aim to reduce adverse effects. These different applications of Eudragit® polymeric nanoparticles could lead to novel products on the market.

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Acknowledgements

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brasil (CAPES)–Finance Code 001.

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Authors and Affiliations

  1. Programa de Pós-Graduação em Farmácia, Faculdade de Farmácia, Universidade Federal da Bahia, 40170-115, Salvador, BA, Brasil

    Ana Maria Lenz Cardoso & Henrique Rodrigues Marcelino

  2. Laboratório de Síntese e Vetorização de Moléculas, Universidade Estadual da Paraíba, 58071-160, João Pessoa, PB, Brasil

    Elquio Eleamen Oliveira

  3. Instituto Senai de Inovação em Sistemas Avançados de Saúde – Centro Universitário SENAI-Cimatec, 41650-010, Salvador, BA, Brasil

    Bruna Aparecida Souza Machado

  4. Departamento do Medicamento – Faculdade de Farmácia, Universidade Federal da Bahia, 40170-115, Salvador, BA, Brasil

    Henrique Rodrigues Marcelino

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  1. Ana Maria Lenz Cardoso
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Cardoso, A.M.L., Oliveira, E.E., Machado, B.A.S. et al. Eudragit®-based nanoparticles for controlled release through topical use. J Nanopart Res 25, 32 (2023). https://doi.org/10.1007/s11051-023-05678-6

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