Abstract
In this article, we describe how it is possible to tune the size and the aspect ratio of gold nanorods obtained using a highly efficient protocol based on the use of hydroquinone as a reducing agent by varying the amounts of CTAB and silver ions present in the “seed-growth” solution. Our approach not only allows us to prepare nanorods with a four times increased Au3+ reduction yield, when compared with the commonly used protocol based on ascorbic acid, but also allows a remarkable reduction of 50–60 % of the amount of CTAB needed. In fact, according to our findings, the concentration of CTAB present in the seed-growth solution do not linearly influence the final aspect ratio of the obtained nanorods, and an optimal concentration range between 30 and 50 mM has been identified as the one that is able to generate particles with more elongated shapes. On the optimized protocol, the effect of the concentration of Ag+ ions in the seed-growth solution and the stability of the obtained particles has also been investigated.
Similar content being viewed by others
References
Alkilany AM, Nagaria PK, Hexel CR, Shaw TJ, Murphy CJ, Wyatt MD (2009) Cellular uptake and cytotoxicity of gold nanorods: molecular origin of cytotoxicity and surface effects. Small 5:701–708
Bao C, Beziere N, del Pino P, Pelaz B, Estrada G, Tian F, Ntziachristos V, de la Fuente JM, Cui D (2013) Gold nanoprisms as optoacoustic signal nanoamplifiers for in vivo bioimaging of gastrointestinal cancers. Small 9:68–74
Chen H, Shao L, Li Q, Wang J (2013) Gold nanorods and their plasmonic properties. Chem Soc Rev 42:2679–2724
Choi WI, Kim J-Y, Kang C, Byeon CC, Kim YH, Tae G (2011) Tumor regression in vivo by photothermal therapy based on gold-nanorod-loaded, functional nanocarriers. ACS Nano 5:1995–2003
Cobley CM, Chen J, Cho EC, Wang LV, Xia Y (2011) Gold nanostructures: a class of multifunctional materials for biomedical applications. Chem Soc Rev 40:44–56
Han G, Ghosh P, Rotello VM (2007) Functionalized gold nanoparticles for drug delivery. Nanomedicine 2:113–123
Howes PD, Rana S, Stevens MM (2014) Plasmonic nanomaterials for biodiagnostics. Chem Soc Rev 43:3835–3853
Huang HA, Barua S, Kay DB, Rege K (2009) Simultaneous enhancement of photothermal stability and gene delivery efficacy of gold nanorods using polyelectrolytes. ACS Nano 3:2941–2952
Katz E, Willner I (2004) Integrated nanoparticle-biomolecule hybrid systems: synthesis, properties, and applications. Angew Chem Int Ed 43:6042–6108
Kinnear C, Burnand D, Clift MJD, Kilbinger AFM, Rothen-Rutishauser B, Petri-Fink A (2014) Polyvinyl alcohol as a biocompatible alternative for the passivation of gold nanorods. Angew Chem Int Ed 53:12613–12617
Mehn D, Morasso C, Vanna R, Bedoni M, Prosperi D, Gramatica F (2013) Immobilised gold nanostars in a paper-based test system for surface-enhanced Raman spectroscopy. Vib Spectrosc 68:45–50
Morasso C, Mehn D, Vanna R, Bedoni M, Forvi E, Colombo M, Prosperi D, Gramatica F (2014) One-step synthesis of star-like gold nanoparticles for surface enhanced raman spectroscopy. Mater Chem Phys 143:1215–1221
Partanen A, Erola MOA, Mutanen J, Lajunen H, Suvanto S, Kuittinen M, Pakkanen TT (2015) Enhancing effects of gold nanorods on luminescence of dyes. J Lumin 157:126–130
Pelaz B, Grazu V, Ibarra A, Magen C, del Pino P, de la Fuente JM (2012) Tailoring the synthesis and heating ability of gold nanoprisms for bioapplications. Langmuir 28:8965–8970
Pérez-Hernández M, Del Pino P, Mitchell SG, Moros M, Stepien G, Pelaz B, Parak WJ, Gálvez EM, Pardo J, de la Fuente JM (2015) Dissecting the molecular mechanism of apoptosis during photothermal therapy using gold nanoprisms. ACS Nano 27:52–61
Perrault SD, Chan WCW (2009) Synthesis and surface modification of highly monodispersed, spherical gold nanoparticles of 50–200 nm. J Am Chem Soc 131:17042–17043
Polo E, del Pino P, Pelaz B, Grazua V, de la Fuente JM (2013) Plasmonic-driven thermal sensing: ultralow detection of cancer markers. Chem Commun 49:3676–3678
Ratto F, Matteini P, Rossi F, Pini R (2010) Size and shape control in the overgrowth of gold nanorods. J Nanopart Res 12:2029–2036
Rayavarapu RG, Ungureanu C, Krystek P, van Leeuwen TG, Manohar S (2010) Iodide impurities in hexadecyltrimethylammonium bromide (CTAB) products: lot–lot variations and influence on gold nanorod synthesis. Langmuir 26:5050–5055
Sau TK, Murphy CJ (2004) Seeded high yield synthesis of short Au nanorods in aqueous solution. Langmuir 20:6414–6420
Saute B, Premasiri R, Ziegler L, Narayanan R (2012) Gold nanorods as surface enhanced Raman spectroscopy substrates for sensitive and selective detection of ultra-low levels of dithiocarbamate pesticides. Analyst 137:5082–5087
Scarabelli L, Grzelczak M, Liz-Marzán LM (2013) Tuning gold nanorod synthesis through prereduction with salicylic acid. Chem Mater 25:4232–4238
Soliman MG, Pelaz B, Parak WJ, del Pino P (2015) Phase transfer and polymer coating methods toward improving the stability of metallic nanoparticles for biological applications. Chem Mater 27:990–997
Vigderman L, Zubarev ER (2013) High-yield synthesis of gold nanorods with longitudinal SPR peak greater than 1200 nm using hydroquinone as a reducing agent. Chem Mater 25:1450–1457
Walsh MJ, Barrow SJ, Tong W, Funston AM, Etheridge J (2015) Symmetry breaking and silver in gold nanorod growth. ACS Nano 9:715–724
Ye X, Jin L, Caglayan H, Chen J, Xing G, Zheng C, Doan-Nguyen V, Kang Y, Engheta N, Kagan CR, Murray CB (2012) Improved size-tunable synthesis of monodisperse gold nanorods through the use of aromatic additives. ACS Nano 6:2804–2817
Zou R, Zhang Q, Zhao Q, Peng F, Wang H, Yu H, Yang J (2010) Thermal stability of gold nanorods in an aqueous solution. Colloids Surf A 372:177–181
Acknowledgments
Funding for this research was provided by Fondazione Cariplo (International Recruitment Call 2011, Project title: “An innovative, nanostructured biosensor for early diagnosis and minimal residual disease assessment of cancer, using Surface Enhanced Raman Spectroscopy”) and by the Italian Ministry of Health under the frame of EuroNanoMed II (European Innovative Research & Technological Development Projects in Nanomedicine, project title: “InNaSERSS”). DP was partly supported by the Regional Foundation for Biomedical Research, Lombardia.
Author information
Authors and Affiliations
Corresponding author
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Morasso, C., Picciolini, S., Schiumarini, D. et al. Control of size and aspect ratio in hydroquinone-based synthesis of gold nanorods. J Nanopart Res 17, 330 (2015). https://doi.org/10.1007/s11051-015-3136-9
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s11051-015-3136-9