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Roles of the cytoskeleton in human diseases

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Abstract

Recently, researches have revealed the key roles of the cytoskeleton in the occurrence and development of multiple diseases, suggesting that targeting the cytoskeleton is a viable approach for treating numerous refractory diseases. The cytoskeleton is a highly structured and complex network composed of actin filaments, microtubules, and intermediate filaments. In normal cells, these three cytoskeleton components are highly integrated and coordinated. However, the cytoskeleton undergoes drastic remodeling in cytoskeleton-related diseases, causing changes in cell polarity, affecting the cell cycle, leading to senescent diseases, and influencing cell migration to accelerate cancer metastasis. Additionally, mutations or abnormalities in cytoskeletal proteins and their related proteins are closely associated with several congenital diseases. Therefore, this review summarizes the roles of the cytoskeleton in cytoskeleton-related diseases as well as its potential roles in disease treatment to provide insights regarding the physiological functions and pathological roles of the cytoskeleton.

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Acknowledgements

Not applicable.

Funding

Funding was provided by the National Natural Science Foundation of China (NSFC) (NO.82071108), the Project of Science and Technology Department of Sichuan Province (NO.2021YJ0228), Research and Develop Program, West China Hospital of Stomatology Sichuan University (NO.LCYJ2020-YJ-3), and the science and technology application demonstration projects in Chengdu (NO.2021-YF09-00078-SN).

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  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cardiology and Endodontics, West China Hospital of Stomatology, Sichuan University, 610021, Chengdu, China

    Mengxin Li, Zhenming Wang, Lijia Liu, Mengjiao Cao, Jingyao Cui, Fanzi Wu & Jing Yang

  2. Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, 610065, Chengdu, China

    Li Peng

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J.Y, M.X.L and L.P designed and developed the original idea in detail, reviewed the literature, and wrote the manuscript. J.Y provided valuable feedback and helped revise the draft. Z.M.W, L.J.L, M.J.C, J.Y.C, and F.Z.W helped to perform the conception of the study with constructive discussions, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript before submission and publication.

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Correspondence to Jing Yang.

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Li, M., Peng, L., Wang, Z. et al. Roles of the cytoskeleton in human diseases. Mol Biol Rep 50, 2847–2856 (2023). https://doi.org/10.1007/s11033-022-08025-5

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