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Cytoskeleton Dynamics in Health and Disease: Role of Molecular Switches and Rheostats

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The Cytoskeleton in Health and Disease

Abstract

Cytoskeleton dynamics provides the platform for most cellular functions and thus underlies a variety of human diseases. While the cytoskeleton cannot be targeted therapeutically, context-specific regulators of its dynamics can provide selective targets. IQGAP1 couples cell growth and division by which it regulates cell homeostasis, dysregulation of which underlies the etiology of many complex human diseases. Fundamental to this role is its regulation of cytoskeleton dynamics and organization of distinct modules that control a plethora of cytoskeleton-anchored cellular functions such as protein traffic and mechanical sensing. The tenet of this chapter is that IQGAP1 serves as a universal molecular rheostat that cells employ, as a sensitive devise, to regulate distinct functions in a precise manner. Selective rewiring of IQGAP1’s subcellular modules has potential for precision medicine.

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Acknowledgement

Work in the MO lab was supported by grants from the NIH-NCI (CA104285) and from ACS.

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Authors and Affiliations

  1. Division of Biology and Medicine, Alpert Medical School, Brown University, Providence, RI, 02912, USA

    Mahasin A. Osman

  2. Savannah State University, Savannah, GA, 31404, USA

    Mahasin A. Osman

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Correspondence to Mahasin A. Osman .

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  1. Department of Veterinary Pathobiology, University of Missouri-Columbia, Columbia, Missouri, USA

    Heide Schatten

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Osman, M.A. (2015). Cytoskeleton Dynamics in Health and Disease: Role of Molecular Switches and Rheostats. In: Schatten, H. (eds) The Cytoskeleton in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2904-7_2

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