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Ionic liquid as an effective green media for the synthesis of (5Z, 8Z)-7H-pyrido[2,3-d]azepine derivatives and recycable Fe3O4/TiO2/multi-wall cabon nanotubes magnetic nanocomposites as high performance organometallic nanocatalyst

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Abstract

In this research we investigated the preparation of new (5Z, 8Z)-7H-pyrido[2,3-d]azepine derivatives in high yields via multicomponent reaction of isatins, alkyl bromides, activated acetylenic compounds and ammonium acetate using ionic liquid 1-octhyl-3-methyl imidazolium bromide ([OMIM]Br) as a stabilizer and soft template at room temperature in the presence of Fe3O4/TiO2/Carbon nanotubes magnetic nanocomposites as a reusable and effective nanocatalyst that are synthesized using ionic liquid [OMIM]Br as a stabilizer, soft template, green media and moderate base. Because of having a NH group in the synthesized pyridine derivatives, we investigate antioxidant property of some synthesized compounds by diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction experiment. Short time of reaction, high yields of product, easy separation of catalyst and products are some advantages of this procedure.

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Acknowledgments

We thank Islamic Azad University of Gorgan, Qaemshahr and Azadshahr for their spiritual support.

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Authors and Affiliations

  1. Department of Chemistry, Azadshahr Branch, Islamic Azad University, Azadshahr, Iran

    Tayyebeh Kohestani, S. Zahra Sayyed-Alangi & Mohammad T. Baei

  2. Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran

    Zinatossadat Hossaini

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  1. Tayyebeh Kohestani
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Kohestani, T., Sayyed-Alangi, S.Z., Hossaini, Z. et al. Ionic liquid as an effective green media for the synthesis of (5Z, 8Z)-7H-pyrido[2,3-d]azepine derivatives and recycable Fe3O4/TiO2/multi-wall cabon nanotubes magnetic nanocomposites as high performance organometallic nanocatalyst. Mol Divers 26, 1441–1454 (2022). https://doi.org/10.1007/s11030-021-10269-5

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