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Heterocycles in drugs and drug discovery

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Heterocycles are common fragments of the vast majority of marketed drugs. This is a reflection of the central role that heterocycles play in modern drug design. They can serve as useful tools to manipulate lipophilicity, polarity, and hydrogen bonding capacity of molecules, which may lead to improved pharmacological, pharmacokinetic, toxicological, and physicochemical properties of drug candidates and ultimately drugs.

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Authors and Affiliations

  1. Global Pharmaceutical Research and Development, Neuroscience Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA

    A. Gomtsyan

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  1. A. Gomtsyan
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Correspondence to A. Gomtsyan.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 12-15, January, 2012.

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Gomtsyan, A. Heterocycles in drugs and drug discovery. Chem Heterocycl Comp 48, 7–10 (2012). https://doi.org/10.1007/s10593-012-0960-z

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  • DOI: https://doi.org/10.1007/s10593-012-0960-z

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