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Thermochemical parameters of phase transitions of antibacterial drugs: sulfamethoxazole, sulfapyridine and sulfamethazine

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Abstract

In the present work, the vapour pressures over solid samples of sulfamethoxazole, sulfapyridine and sulfamethazine were measured by fast scanning calorimetry (FSC). Due to the thermal decomposition of the samples, it was not possible to measure the vapour pressure of these compounds by transpiration method. The IR spectrum of the condensed sample in the sulfamethoxazole transpiration experiment showed that the transferred substance was 5-methyl-3-isoxazolamine. The temperature dependencies of the vapour pressure determined using FSC were used to determine the enthalpy of sublimation at the mean temperature of the experiment. Fusion enthalpies and heat capacities of solid and supercooled liquid samples of sulfamethoxazole, sulfapyridine and sulfamethazine were measured by differential and fast scanning calorimetries. The dependencies of the heat capacity over wide temperature ranges were approximated by linear equations. The fusion enthalpies were compared with literature data and used to calculate weighted averages. The weighted mean values of the fusion enthalpies at the melting temperature were adjusted to 298.15 K using Kirchhoff’s law. In addition, the values of the heat capacity difference between the solid and gaseous phases were estimated using the experimental values of the heat capacities and the empirical approach. These values were used to adjust the enthalpy of sublimation from experimental temperature to 298.15 K. Using the sublimation and fusion enthalpies, the vaporization enthalpies of three sulfonamides at 298.15 K were determined.

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Acknowledgements

This work was supported by the Russian Science Foundation (RSF Grant 22-23-00312), https://rscf.ru/en/project/22-23-00312/. The authors thank technician Alexander E. Klimovitskii for the careful IR spectroscopy experiments.

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Authors and Affiliations

  1. Department of Physical Chemistry, Kazan Federal University, Kremlevskaya Str. 18, 420008, Kazan, Russia

    Ruslan N. Nagrimanov, Almaz R. Italmasov, Aleksey V. Buzyurov, Semen E. Lapuk, Radik A. Larionov, Alexander V. Gerasimov & Marat A. Ziganshin

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  1. Ruslan N. Nagrimanov
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Contributions

RNN contributed to writing—original draft preparation. AAI was involved in writing—review and editing. AVB contributed to writing—review and editing. SEL was involved in investigation. RAL contributed to investigation. AVG was involved in investigation. MAZ contributed to investigation.

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Correspondence to Ruslan N. Nagrimanov.

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Nagrimanov, R.N., Italmasov, A.R., Buzyurov, A.V. et al. Thermochemical parameters of phase transitions of antibacterial drugs: sulfamethoxazole, sulfapyridine and sulfamethazine. J Therm Anal Calorim 149, 1433–1442 (2024). https://doi.org/10.1007/s10973-023-12757-2

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