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Multifunctional Silver Nanoparticles-Decorated Silica Functionalized with Retinoic Acid with Anti-Proliferative and Antimicrobial Properties

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Abstract

The paper describes a rapid and simple method for preparing a multifunctional biomaterial based on retinoic acid covalently bound on silica@Ag particles. Monodispersed SiO2 particles were prepared by Stöber method and further used for loading the Ag nanoparticles on their surface. This composite was further functionalized with retinoic acid. Characterization of the hybrid materials was made by UV–Visible spectroscopy, Transmission electron microscopy, Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and Thermal analysis. The biological evaluation of the obtained materials revealed their potential use for multiple biomedical applications, from anti-proliferative agents to novel antimicrobial and antibiofilm strategies.

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Acknowledgments

Authors would like to thanks the Romanian National Authority for Scientific Research (CNCS-UEFISCDI) for financial support (Grant PN-II-RU-PD-2012-3-0090). Project INFRANANOCHEM-19/01.03.2009 funded by EU (ERDF) and Romanian Government is gratefully acknowledged for the TEM and DLS equipments.

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Authors and Affiliations

  1. Institute of Physical Chemistry “Ilie Murgulescu”, Romanian Academy, 060021, Bucharest, Romania

    Madalina Tudose, Daniela C. Culita, Adina M. Musuc, Gabriela Marinescu, Simona Somacescu & Cornel Munteanu

  2. St. S. Nicolau Virology Institute, 285 Mihai Bravu Avenue, Sector 3, PO 77, 030304, PO Box 201, Bucharest, Romania

    Coralia Bleotu

  3. Microbiology Immunology Department, Faculty of Biology, University of Bucharest, Aleea Portocalelor 1-3, Bucharest, Romania

    Mariana C. Chifiriuc

  4. Research Institute of the University of Bucharest, Spl. Independentei 91-95, Bucharest, Romania

    Mariana C. Chifiriuc

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  1. Madalina Tudose
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  2. Daniela C. Culita
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  3. Adina M. Musuc
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  4. Gabriela Marinescu
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  8. Mariana C. Chifiriuc
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Correspondence to Madalina Tudose or Mariana C. Chifiriuc.

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Tudose, M., Culita, D.C., Musuc, A.M. et al. Multifunctional Silver Nanoparticles-Decorated Silica Functionalized with Retinoic Acid with Anti-Proliferative and Antimicrobial Properties. J Inorg Organomet Polym 26, 1043–1052 (2016). https://doi.org/10.1007/s10904-016-0407-6

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