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Ultrasensitive and Rapid Determination of Folic Acid Using Ag Nanoparticles Enhanced 1, 10-Phenantroline-Terbium (III) Sensitized Fluorescence

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Abstract

A novel spectrofluorimetric probe based on Ag nanoparticle (AgNPs)-enhanced terbium (III) (Tb) fluorescence was introduced for the sensitive determination of folic acid (FA). The effect of gold and silver nanoparticles in different size was investigated on the well-known Tb sensitized fluorescence emission of 1, 10-phenantroline (Phen). The greatest fluorescence intensity was observed in the presence of AgNPs with a diameter of ~6 nm maybe due to their highest surface area. Furthermore, it’s discovered that FA can form Tb-Phen -FA ternary complexes and cause a notable diminution in this enhanced fluorescence system. Based on this finding, a high sensitive and selective method was developed for the determination of FA. Effects of various parameters like Ag NPs, Phen and Tb3+ concentration and pH of media were investigated. In the optimum circumstances, the fluorescence emission of AgNPs-Phen-Tb collection was declined linearly by increasing the concentration of FA in the range of 0.5 to 110 nmol L−1. Limits of detection and quantification were achieved to be 0.21 and 0.62 nmol  L−1, respectively. The method has good linearity, recovery, reproducibility and sensitivity, and was adequately exploited to follow FA content in pharmaceutical, fortified flour and human urine samples.

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Authors and Affiliations

  1. Department of Midwifery, Bonab Branch, Islamic Azad University, Bonab, Iran

    Robab Hassanzadeh

  2. Tabriz Branch, Islamic Azad University, Tabriz, Iran

    Ali lotfi & Javad Hassanzadeh

  3. Department of Chemistry, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, East Azarbaijan, Iran

    Nafiseh Bagheri

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  1. Robab Hassanzadeh
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  2. Ali lotfi
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  3. Nafiseh Bagheri
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  4. Javad Hassanzadeh
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Correspondence to Javad Hassanzadeh.

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Hassanzadeh, R., lotfi, A., Bagheri, N. et al. Ultrasensitive and Rapid Determination of Folic Acid Using Ag Nanoparticles Enhanced 1, 10-Phenantroline-Terbium (III) Sensitized Fluorescence. J Fluoresc 26, 1875–1883 (2016). https://doi.org/10.1007/s10895-016-1882-4

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  • DOI: https://doi.org/10.1007/s10895-016-1882-4

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