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Phytogenic Titanium Dioxide (TiO2) Nanoparticles Derived from Rosa davurica with Anti-bacterial and Anti-biofilm Activities

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Abstract

This work reports the synthesis, antibacterial and anti-biofilm activities of titanium dioxide nanoparticles (RDL-TiO2NPs) from Rosa davurica leaf extract. The RDL-TiO2NPs were characterized using TEM-EDS, FTIR, DLS, and XRD analysis. The characterization results indicated that RDL-TiO2NPs were anatase particle-sized 146 ± 3 nm with a surface charge of − 23.53 ± 1.36 mV. The MIC, MBC, and IC50 of RDL-TiO2NPs were significantly varied among the targeted bacterial pathogens (p < 0.05). The MIC of RDL-TiO2 NPs were exhibited 15.62 μg/mL for S. aureus and B. cereus, 31.25 μg/mL for E. coli and 62.5 μg/mL for S. enterica. The MBC were found to be 125 μg/mL for S. aureus and B. cereus while 250 μg/mL for E. coli and S. enterica. The IC50 was exhibited higher (158.75 μg/mL) for S. enterica and lower (76.84 μg/mL) for S. aureus. Further, the TEM and crystal violet staining assays revealed that RDL-TiO2NPs inhibited bacterial biofilm by damaging the cell wall membrane. Overall, this work indicated that RDL-TiO2NPs is a promising antibacterial agent deserves further molecular elucidation.

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Acknowledgements

This work was supported by the Yangzhou University International academic exchange fund (YZUIAEF201901020) and Jiangsu Province Graduate Practice Innovation Project (SJCX19_0892), China.

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Authors and Affiliations

  1. College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China

    Yingshan Jin & Bing Li

  2. Department of Bio-Health Convergence, Kangwon National University, Chuncheon, 200-701, South Korea

    Kandasamy Saravanakumar, Xiaowen Hu & Myeong-Hyeon Wang

  3. Department of Medical Biotechnology, College of Biomedical Sciences, Kangwon National University, Chuncheon, 200-701, South Korea

    Myeong-Hyeon Wang

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  1. Yingshan Jin
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  2. Bing Li
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  3. Kandasamy Saravanakumar
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Correspondence to Myeong-Hyeon Wang.

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Jin, Y., Li, B., Saravanakumar, K. et al. Phytogenic Titanium Dioxide (TiO2) Nanoparticles Derived from Rosa davurica with Anti-bacterial and Anti-biofilm Activities. J Clust Sci 33, 1435–1443 (2022). https://doi.org/10.1007/s10876-021-02024-5

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