Abstract
The green synthesis of nanoparticles is a convenient, inexpensive, rapid and eco-friendly method compared to traditional synthesis methods. We synthesized iron oxide nanoparticles (α-Fe2O3 (hematite)) nanoparticles from iron (III) chloride using an aqueous extract of Psoralea corylifolia seeds as a reducing agent. Various characterization methods indicate that nanoparticles were crystalline with an average size of ~39 nm. The nanoparticles were assessed for their catalytic activity on methylene blue using a UV–Vis spectrophotometer and showed a rapid reduction within 63 min. The in vitro anticancer activity of the nanoparticles was also determined by Sulforhodamine (SRB) assay, and caspase-3 expression was determined using caspase-3 fluorescence and immunofluorescence assays. The results were suggested the strong cancer cell growth inhibition in a dose-dependent manner.
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Acknowledgments
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2015R1A2A2A01003741). This work was also supported by KU-Research Professor Program, Konkuk University, Seoul, South Korea.
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P.C. Nagajyoth and Muthuraman Pandurangan has contributed equally to this work.
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Nagajyothi, P.C., Pandurangan, M., Kim, D.H. et al. Green Synthesis of Iron Oxide Nanoparticles and Their Catalytic and In Vitro Anticancer Activities. J Clust Sci 28, 245–257 (2017). https://doi.org/10.1007/s10876-016-1082-z
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DOI: https://doi.org/10.1007/s10876-016-1082-z