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The Node of Ranvier in Multifocal Motor Neuropathy

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Abstract

Multifocal motor neuropathy affects myelinated motor axons in limb nerves at multifocal sites. It is characterized by weakness and muscle atrophy, motor conduction block, and antibodies against ganglioside GM1 which is expressed on the axolemma of nodes of Ranvier and perinodal Schwann cells. Treatment by regular IVIg courses results in temporary improvement but cannot prevent slowly progressing weakness due to axonal degeneration. This review discusses possible mechanisms of conduction block and the reasons why motor axons are selectively affected in this disorder.

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Authors and Affiliations

  1. Department of Neuromuscular Disorders, Brain Center Rudolf Magnus, University Hospital Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands

    Hessel Franssen

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  1. Hessel Franssen
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Correspondence to Hessel Franssen.

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Franssen, H. The Node of Ranvier in Multifocal Motor Neuropathy. J Clin Immunol 34 (Suppl 1), 105–111 (2014). https://doi.org/10.1007/s10875-014-0023-6

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  • DOI: https://doi.org/10.1007/s10875-014-0023-6

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