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Synthesis and characterization of PLGA/collagen composite scaffolds as skin substitute produced by electrospinning through two different approaches

  • Engineering and Nano-engineering Approaches for Medical Devices
  • Original Research
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Abstract

Skin damage can occur for many reasons, including burns and injuries, which in extreme cases can even lead to death. Different methods such as electrospinning are used to produce scaffolds used in skin tissue engineering. Natural and synthetic polymers were used in this method. It was observed that the use of both natural and synthetic polymers gives better results for cell culturing rather than using of each material solely. In this study, scaffolds of poly(lactic-co-glycolic acid) and collagen were prepared using coating and common solvent methods. The characteristics of samples were evaluated through scanning electron microscopy, porosimetry, mechanical testing, degradation behavior, and in vitro assays. The mechanical and biocompatibility test results of the scaffold prepared by coating method were better than the other one. However, the degradation rate of the common solvent was nearly five times more than coating sample that leads to cytotoxicity in contact with the skin cells.

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Acknowledgments

The authors wish to acknowledge the central office of Academic Centre for Education, Culture and Research (ACECR, Grant No. 2641-21) for their financial support of this research as well as Dr. Mahdavi for his language editing of this manuscript.

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Authors and Affiliations

  1. Department of Materials Research, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran

    Ali Reza Sadeghi-avalshahr, Mohammad Khorsand-Ghayeni, Samira Nokhasteh & Amir Mahdi Molavi

  2. Materials Engineering Department, Tarbiat Modares University, Tehran, Iran

    Amir Mahdi Molavi

  3. Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran

    Hojjat Naderi-Meshkin

Authors
  1. Ali Reza Sadeghi-avalshahr
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  2. Mohammad Khorsand-Ghayeni
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  3. Samira Nokhasteh
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  4. Amir Mahdi Molavi
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  5. Hojjat Naderi-Meshkin
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Correspondence to Ali Reza Sadeghi-avalshahr.

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Sadeghi-avalshahr, A.R., Khorsand-Ghayeni, M., Nokhasteh, S. et al. Synthesis and characterization of PLGA/collagen composite scaffolds as skin substitute produced by electrospinning through two different approaches. J Mater Sci: Mater Med 28, 14 (2017). https://doi.org/10.1007/s10856-016-5789-z

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  • DOI: https://doi.org/10.1007/s10856-016-5789-z

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