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Poly (lactide-co-glycolide)-based nanocomposite reinforced by a novel hybrid nanohydroxyapatite

  • Composites & nanocomposites
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Abstract

To obtain a high-performance poly(lactide-co-glycolide) (PLGA)-based composite, a novel functionalized hybrid nanohyoxyapatite (n-HA) was proposed by introducing carboxymethyl-β-cyclodextrin (CMCD) and zoledronic acid (ZA). IR, XRD, TGA, dispersion experiments for hybrid n-HA and universal testing machine, SEM, DSC, POM for the hybrid n-HA/PLGA composite were carried out. The results showed that initial adjusted pH = 11 was more favor for the grafting rate of CMCD, and ZA was preferentially grafted on n-HA surface due to stronger binding ability to Ca2+. The high content of CMCD and ZA of 40%CMCD-10%ZA-n-HA could be well dispersed in organic solvents, which could effectively promote crystallization, so that CMCD-ZA-n-HA displayed the best reinforce effect for PLGA, whose tensile strength and elongation at break were 16.20 and 41.99% higher than PLGA, respectively. In vitro soaking in simulated body fluid (SBF) and cell proliferation results demonstrated that CMCD-ZA-n-HA endowed PLGA with faster degradation, better bone-like apatite deposition and cells adhesion and proliferation ability. The study would provide a new simply method to obtain a functionalized hybrid n-HA, which had a great potential to obtain ideal n-HA/PLGA composite used in the bone materials field.

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Acknowledgements

This work was financially supported by Postgraduate Scientific Research Innovation Project of Hunan Province (CX20230518).

Funding

Postgraduate Scientific Research Innovation Project of Hunan Province, CX20230518, Shuo Tang.

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Authors and Affiliations

  1. National & Local Joint Engineering Laboratory for New Petro-Chemical Materials and Fine Utilization of Resources, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, People’s Republic of China

    Liuyun Jiang, Yingjun Ma, Shuo Tang, Yan Zhang & Shengpei Su

  2. Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, People’s Republic of China

    Liuyun Jiang, Yingjun Ma, Shuo Tang, Yan Zhang & Shengpei Su

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  1. Liuyun Jiang
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  2. Yingjun Ma
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  3. Shuo Tang
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  4. Yan Zhang
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  5. Shengpei Su
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Contributions

LJ and YM conceived and designed the experiments. YM performed the experiments including fabrication and analysis. ST, LJ, YZ and SS wrote the paper.

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Correspondence to Liuyun Jiang or Yan Zhang.

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Jiang, L., Ma, Y., Tang, S. et al. Poly (lactide-co-glycolide)-based nanocomposite reinforced by a novel hybrid nanohydroxyapatite. J Mater Sci 58, 16954–16971 (2023). https://doi.org/10.1007/s10853-023-09096-w

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