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The role of CoQ10 in embryonic development

  • Embryo Biology
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Coenzyme Q10 (CoQ10) is a natural component widely present in the inner membrane of mitochondria. CoQ10 functions as a key cofactor for adenosine triphosphate (ATP) production and exhibits antioxidant properties in vivo. Mitochondria, as the energy supply center of cells, play a crucial role in germ cell maturation and embryonic development, a complicated process of cell division and cellular differentiation that transforms from a single cell (zygote) to a multicellular organism (fetus). Here, we discuss the effects of CoQ10 on oocyte maturation and the important role of CoQ10 in the growth of various organs during different stages of fetal development. These allowed us to gain a deeper understanding of the pathophysiology of embryonic development and the potential role of CoQ10 in improving fertility quality. They also provide a reference for further developing its application in clinical treatments.

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Funding

This work was supported by National Key Research and Development Project (2019YFA0801601 to Zhisheng Jiang), National Natural Science Foundation of China (No. 32101018 to Miao Jiang), and Hunan Provincial Natural Science Foundation of China (No. 2023JJ30522 to Miao Jiang).

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  1. Zhisheng Jiang

    Present address: Institute of Cardiovascular Disease, Department of Pathophysiology, Key Laboratory for Arteriosclerology of Hunan Province, Postdoctoral Research Station of Basic Medicine, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang, 421001, China

Authors and Affiliations

  1. Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China

    Xueke He, Hao Chen, Minjun Liao & Miao Jiang

  2. College of Public Health, University of South China, Hengyang, 421001, Hunan, China

    Xiaomei Zhao

  3. Group On the Molecular and Cell Biology of Lipids, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada

    Dawei Zhang

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Conceptualization, Xueke He and Miao Jiang; resources, Xueke He and Minjun Liao; writing—original draft preparation, Xueke He; writing—review and editing, Xueke He, Hao Chen, Minjun Liao, Xiaomei Zhao, Miao Jiang, and Da-wei Zhang; supervision, Miao Jiang; funding acquisition, Miao Jiang and Zhisheng Jiang. All authors have read and agreed to the published version of the manuscript.

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He, X., Chen, H., Liao, M. et al. The role of CoQ10 in embryonic development. J Assist Reprod Genet 41, 767–779 (2024). https://doi.org/10.1007/s10815-024-03052-6

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