Abstract
Purpose
To compare the perceived pain and estimated operative duration among patients undergoing bilateral cataract surgery and to demonstrate correlations with the surgical interval and the demographic and medical characteristics of the patients.
Methods
A total of 466 patients with cataract who underwent ocular surgery were included. The patients estimated the perceived operative duration and pain they felt during the operation at two times, immediately after surgery and on the first postoperative day; pain was scored using a visual analog scale ranging from 0 (no pain) to 10 (unbearable pain). Patients undergoing bilateral surgeries were divided into four subgroups based on the interval between the two operations (1, 2, 4, or 6 weeks). The perceived pain score and the estimated operative duration were the primary outcomes.
Results
The pain scores were higher for the second surgery than for the first surgery both immediately after surgery (P = 0.043) and on the first postoperative day (P = 0.002). The estimated operative duration was longer for the second surgery (P = 0.001). Only patients who underwent the second surgery at an interval of 2 weeks perceived more pain both immediately and 1 day postoperatively (P = 0.002, P = 0.022) and a longer operative duration (P < 0.001). Gender, age, and education level might also influence the pain score.
Conclusions
Female patients, patients with a younger age, and patients with higher education level are likely to report more pain. Patients who require bilateral cataract surgery should not undergo the second surgery before an interval of 2 weeks.
Similar content being viewed by others
Data sharing statement
The total data of the study could be got on the ResMan platform (www.medresman.org) for 5 years (from 2018 to 2023).
References
Pascolini D, Mariotti SP (2012) Global estimates of visual impairment: 2010. Br J Ophthalmol 96:614–618
Ursea R, Feng MT, Zhou M, Lien V, Loeb R (2011) Pain perception in sequential cataract surgery: comparison of first and second procedures. J Cataract Refract Surg 37:1009–1014
Adatia FA, Munro M, Jivraj I, Ajani A, Braga-Mele R (2015) Documenting the subjective patient experience of first versus second cataract surgery. J Cataract Refract Surg 41:116–121
Akkaya S, Özkurt YB, Aksoy S, Kökçen HK (2017) Differences in pain experience and cooperation between consecutive surgeries in patients undergoing phacoemulsification. Int Ophthalmol 37:545–552
Sharma N, Ooi J, Figueira E et al (2007) Patient perceptions of second eye clear corneal cataract surgery using assisted topical anaesthesia. Eye 22:547–550
Bardocci A, Ciucci F, Lofoco G, Perdicaro S, Lischetti A (2011) Pain during second eye cataract surgery under topical anesthesia: an intraindividual study. Graefe’s Arch Clin Exp Ophthalmol 249:1511–1514
Hari-Kovacs A, Lovas P, Facsko A, Crate ID (2012) Is second eye phacoemulsification really more painful? Wien Klin Wochenschr 124:516–519
Aslankurt M, Aslan L, Başkan AM et al (2014) Pain and cooperation in patients having dominant-side or nondominant-side phacoemulsification. J Cataract Refract Surg 40:199–202
Yu J, Ye T, Huang Q et al (2016) Comparison between subjective sensations during first and second phacoemulsification eye surgeries in patients with bilateral cataract. J Ophthalmol 2016:1–6
Johnston RL, Whitefield LA, Giralt J et al (1998) Topical versus peribulbar anesthesia, without sedation, for clear corneal phacoemulsification. J Cataract Refract Surg 24:407
Omulecki W, Laudanska-Olszewska I, Synder A (2009) Factors affecting patient cooperation and level of pain perception during phacoemulsification in topical and intracameral anesthesia. Eur J Ophthalmol 19:977–983
Edwards RR, Goble L, Kwan A et al (2006) Catastrophizing, pain, and social adjustment in scleroderma: relationships with educational level. Clin J Pain 22:639–646
Lofoco G, Ciucci F, Bardocci A et al (2008) Efficacy of topical plus intracameral anesthesia for cataract surgery in high myopia: randomized controlled trial. J Cataract Refract Surg 34:1664–1668
Wilbrandt HR, Wilbrandt TH (1994) Pathogenesis and management of the lens-iris diaphragm retropulsion syndrome during phacoemulsification. J Cataract Refr Surg 20:48
Eke T, Thompson JR (2007) Serious complications of local anaesthesia for cataract surgery: a 1 year national survey in the United Kingdom. Br J Ophthalmol 91:470–475
Khezri MB, Merate H (2013) The effects of melatonin on anxiety and pain scores of patients, intraocular pressure, and operating conditions during cataract surgery under topical anesthesia. Indian J Ophthalmol 61:319–324
Jacobi PC, Dietlein TS, Jacobi FK (2000) A comparative study of topical vs retrobulbar anesthesia in complicated cataract surgery. Arch Ophthalmol 118:1037–1043
Zhao L, Zhu H, Zhao P, Wu Q, Hu Y (2012) Topical anesthesia versus regional anesthesia for cataract surgery: a meta-analysis of randomized controlled trials. Ophthalmology 119:659–667
Jiang L, Zhang K, He W et al (2015) Perceived pain during cataract surgery with topical anesthesia: a comparison between first-eye and second-eye surgery. J Ophthalmol 2015:383456
Zhu X, Wolff D, Zhang K et al (2015) Molecular inflammation in the contralateral eye after cataract surgery in the first eye. Investig Ophthalmol Vis Sci 56:5566
Zhang Y, Du Y, Jiang Y, Zhu X, Lu Y (2018) Effects of pranoprofen on aqueous humor monocyte chemoattractant protein-1 level and pain relief during second-eye cataract surgery. Front Pharmacol 9:783
Belmonte C, Acosta MC, Schmelz M, Gallar J (1999) Measurement of corneal sensitivity to mechanical and chemical stimulation with a CO2 esthesiometer. Investig Ophthalmol Vis Sci 40:513
Müller LJ, Marfurt CF, Kruse F, Tervo TMT (2003) Corneal nerves: structure, contents and function. Exp Eye Res 76:521–542
Leonardi A (2002) The central role of conjunctival mast cells in the pathogenesis of ocular allergy. Curr Allergy Asthma Rep 2:325–331
Oetjen LK, Mack MR, Feng J et al (2017) Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch. Cell 171:217–228
Huang CC, Yang W, Guo C et al (2018) Anatomical and functional dichotomy of ocular itch and pain. Nat Med 24:1268–1276
Sugita S, Taguchi C, Takase H et al (2000) Soluble Fas ligand and soluble Fas in ocular fluid of patients with uveitis. Br J Ophthalmol 84:1130–1134
Acknowledgements
We would like to thank all the patients enrolled in the trial and the nurses’ patience for those patients more painful.
Funding
The study was funded by the National Natural Science Foundation of China (No. 81870647).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the ethics committee of the Third Affiliated Hospital of Army Medical University and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Liu, P., Zhang, S., Geng, Z. et al. Factors affecting pain in patients undergoing bilateral cataract surgery. Int Ophthalmol 40, 297–303 (2020). https://doi.org/10.1007/s10792-019-01178-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10792-019-01178-6