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Inhibitory neurotransmitter serotonin and excitatory neurotransmitter dopamine both decrease food intake in Chinese perch (Siniperca chuatsi)

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Abstract

Aminergic neurotransmitters play important roles in the regulation of food intake. However, their effects on feeding in fish have been less explored and still unclear. In the present study, the effects of serotonin (5-HT) and dopamine (DA) on food intake were evaluated through intraventricular (ICV) administration in Chinese perch (Siniperca chuatsi) and the mRNA expression levels of neuropeptide Y (NPY), agouti gene-related protein (AgRP), and pro-opiomelanocortin (POMC) were detected. At 1 h post-injection, 5-HT significantly decreased food intake in a dose-dependent manner. The mRNA expression of NPY and AgRP were significantly decreased (p < 0.05), whereas the mRNA expression of POMC was significantly increased (p < 0.05), suggesting the involvement of NPY, AgRP, and POMC in inhibitory action of 5-HT on food intake in Chinese perch. DA significantly decreased (p < 0.05) food intake and AgRP mRNA expression at 1 h post-injection, indicating the inhibitory effect of DA on food intake might be mediated through AgRP. This might shed new light on the regulation of food intake in Chinese perch.

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Acknowledgments

This work was financially supported by the National Basic Research Program of China (2014CB138601) and the National Natural Science Foundation of China (31602131).

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  1. Yu-Hui He and Ling Li contributed equally to this work.

Authors and Affiliations

  1. College of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, Wuhan, 430070, China

    Yu-Hui He, Ling Li, Xu-Fang Liang, Shan He, Luo Zhao & Yan-Peng Zhang

  2. Freshwater Aquaculture Collaborative Innovation Center of Hubei Province, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan, 430070, China

    Yu-Hui He, Ling Li, Xu-Fang Liang, Shan He, Luo Zhao & Yan-Peng Zhang

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  1. Yu-Hui He
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Correspondence to Xu-Fang Liang.

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He, YH., Li, L., Liang, XF. et al. Inhibitory neurotransmitter serotonin and excitatory neurotransmitter dopamine both decrease food intake in Chinese perch (Siniperca chuatsi). Fish Physiol Biochem 44, 175–183 (2018). https://doi.org/10.1007/s10695-017-0422-8

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