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The assessment of multifocal ERG responses in school-age children with history of prematurity

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Abstract

Purpose

The authors examined macular function in preterm-born children, using multifocal ERG (mfERG). Possible alterations in P1 amplitudes, P1 amplitudes density and P1 implicit time between school-age children with history of prematurity and their peers were researched. The correlations between parameters of mfERG responses and birth weight, gestational age, macular volume and central macular thickness were verified.

Methods

A group of 18 preterm-born school-age children were analyzed (mean age 10.18 ± 1.21 years). The study group was compared to the group of 15 peers born appropriate for gestational age (mean age 10.8 ± 1.52 years). The mfERG was evaluated in all children.

Results

There were statistically significant differences for P1 amplitudes from ring 1 (p = 0.0001) and P1 amplitudes density from ring 1 (p = 0.0001). Calculating the correlation coefficients, we receive significant results for P1 amplitudes from ring 1 versus gestational age (r = 0.54; p = 0.026), birth weight (r = 0.54; p = 0.026) and central macular thickness (r = −0.62; p = 0.008), and for P1 amplitudes density from ring 1 versus central macular thickness (r = −0.51; p = 0.034).

Conclusions

The study suggests that P1 amplitudes and P1 amplitudes density vary in preterm-born children in comparison with their peers born appropriate for gestational age, which might suggest discreet macular dysfunction. The correlation between low birth weight, early gestational age, central macular thickness and mFERG components from ring 1 might evidence that decreased bipolar cells density caused by premature birth is the result of altered development of central retina reflecting in structural anomalies of the fovea.

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Authors and Affiliations

  1. Department of Paediatric Ophthalmology and Strabismus, Medical University of Białystok, Waszyngtona 17, 15-274, Białystok, Poland

    Marta Michalczuk, Beata Urban, Beata Chrzanowska-Grenda, Monika Oziębło-Kupczyk & Alina Bakunowicz-Łazarczyk

  2. Faculty of Computer Science, Białystok University of Technology, Wiejska 45A, 15-351, Białystok, Poland

    Małgorzata Krętowska

Authors
  1. Marta Michalczuk
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  2. Beata Urban
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  3. Beata Chrzanowska-Grenda
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  4. Monika Oziębło-Kupczyk
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  6. Małgorzata Krętowska
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Correspondence to Marta Michalczuk.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the parents of all children included in the study.

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Michalczuk, M., Urban, B., Chrzanowska-Grenda, B. et al. The assessment of multifocal ERG responses in school-age children with history of prematurity. Doc Ophthalmol 132, 47–55 (2016). https://doi.org/10.1007/s10633-016-9526-1

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  • DOI: https://doi.org/10.1007/s10633-016-9526-1

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