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A New Flavonoid Glycoside and Other Constituents from Sedum sarmentosum with Anti-Inflammatory Activity

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Chemistry of Natural Compounds Aims and scope

One new flavonol glycoside (1), together with one known flavonol glycoside (2) and 16 known megastigmanes (3–18) were isolated from the whole plant of Sedum sarmentosum Bunge. Their structures were established by spectroscopic data (1D, 2D NMR, and HR-ESI-MS) and comparison with the literature. Among them, compounds 8 and 10–12 were reported from the Crassulaceae family for the first time. Anti-inflammatory effects of the isolated compounds were evaluated in terms of inhibition of NO, TNF-α, and IL-6 production in lipopolysaccharide-stimulated RAW 264.7 cells. Compounds 8 and 16 could inhibit NO production with IC50 values of 47.93 ± 3.43 μM and 47.11 ± 3.63 μM. Compounds 4 and 6 showed an inhibitory effect on IL-6 production with IC50 values of 34.37 ± 4.84 μM and 38.26 ± 3.32 μM.

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Acknowledgment

This work was supported by the Natural Science Foundation of Jilin Province, Jilin, China (Grant No. 20200201034JC) and the Jilin Provincial Education Department (JJKH20200534KJ). We thank Alison McGonagle, PhD, from Liwen Bianji, Edanz Group China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript.

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Authors and Affiliations

  1. Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, 133002, Yanji, P. R. China

    Tieqiang Zong, Wei Zhou & Gao Li

  2. College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, 473061, Nanyang, P. R. China

    Yi Zhou

  3. Department of Pharmacy, Yanbian University Hospital, 133000, Yanji, P. R. China

    Zhe Jiang & Mei Jin

Authors
  1. Tieqiang Zong
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  2. Yi Zhou
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  5. Wei Zhou
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Corresponding authors

Correspondence to Wei Zhou or Gao Li.

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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2023, pp. 213–216.

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Zong, T., Zhou, Y., Jiang, Z. et al. A New Flavonoid Glycoside and Other Constituents from Sedum sarmentosum with Anti-Inflammatory Activity. Chem Nat Compd 59, 249–253 (2023). https://doi.org/10.1007/s10600-023-03968-y

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  • DOI: https://doi.org/10.1007/s10600-023-03968-y

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