Abstract
Sixteen known compounds, including three lignan glycosides (1–3), seven phenolic glycosides (4–10), three glycosides (11–13), and three flavonoids (14–16), were isolated from the rhizomes of Actinidia kolomikta (Rupr. & Maxim.) Maxim., Actinidiaceae. Their structures were elucidated through extensive spectroscopic analyses and comparison with those reported in the literature. This study is the first confirmation of the presence of the twelve compounds (1–4, 6–13) isolated from the Actinidiaceae family. The isolated compounds were evaluated for their inhibitory effects on NO, TNF-α, and IL-6 production in LPS-induced RAW264.7 cells. Among them, salidroside (9), D-threo-guaiacylglycerol 7-O-β-D-glucopyranoside (10), and epi-afzelechin (15) exhibited the potent anti-inflammatory effect against NO, TNF-α, and IL-6. In addition, compound 10 showed significant inhibitory effects on COX-2 expression at 50 μM, and compound 15 showed significant inhibitory effects on iNOS expression at 50 μM. These results suggest that the anti-inflammatory activity of A. kolomikta might in part occur via the inhibition of the expression of the pro-inflammatory cytokines.
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Change history
26 March 2020
This article was updated to include the chemical structures missed during the production process.
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Acknowledgments
We thank Alison McGonagle, PhD, from Liwen Bianji, Edanz Group China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript.
Funding
This work was supported by the National Natural Science Foundation of China under Grant numbers (81660699, 81660579, and 81760627).
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CY and JS carried out the extract, isolation, purification, and running the laboratory work. MJ, RL, CJ, LJ, and YJM contributed to biological studies. WZ and GL contributed equally to this paper on structural determination and writing this paper.
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Ye, C., Jin, M., Jin, C. et al. Inhibitory Effects of Chemical Constituents from Actinidia kolomikta on LPS-Induced Inflammatory Responses. Rev. Bras. Farmacogn. 30, 127–131 (2020). https://doi.org/10.1007/s43450-020-00004-w
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DOI: https://doi.org/10.1007/s43450-020-00004-w