A total of 20 new indole analogs were synthesized and evaluated for biological activity against Sclerotinia sclerotiorum, Altenaria solani, Verticillium dahliae, Fusarium oxysporum, Pythium walnuts, and Curvularia zea. The preliminary biological testing showed that most of the synthesized compounds exhibited fungicidal activities. Notably, compounds 2 and 7 showed the broadest and most effective activities among the compounds tested and could be potential new lead compounds for the future development of antifungal agents.
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This work was supported by Zhoushan Public Welfare Science and Technology Project (2019C31066) and the National Science and Foundation of China (32271543).
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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2023 pp. 98–104
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Zheng, S., Jiang, Q., Massande, G.N. et al. Synthesis and Antifungal Activity of Indole Derivatives. Chem Nat Compd 59, 111–118 (2023). https://doi.org/10.1007/s10600-023-03929-5
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DOI: https://doi.org/10.1007/s10600-023-03929-5