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A Novel Compound from the Bark of Diospyros lotus and their Urease Inhibitory Activity

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Chemistry of Natural Compounds Aims and scope

One novel dimeric naphthoquinone, 1′,4′-dihydroxy-5,8-dimethoxy-11,11′-dimethyl-[7,3′-binaphthalene]-1,4,5′,8′-tetraone, was isolated from the chloroform-soluble fraction of Diospyros lotus bark. The chemical structure of compound 1 was elucidated by advanced spectroscopy techniques, such as 1H, 13C NMR, HMBC, HSQC, COSY, and NOSEY. The chloroform extract and compound 1 were evaluated for their urease inhibitory activity, which showed excellent results with IC50 value of 421.21 and 68.42 μM, respectively, against thiourea (IC50 = 21.24 μM).

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Acknowledgment

The authors are grateful to the Higher Education Commission (HEC) of Pakistan and to Qassim University, Saudia Arabia for providing the facilities for the conduct of the study.

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Authors and Affiliations

  1. Department of Chemistry, University of Swabi, Swabi, Anbar KPK, Pakistan

    Abdur Rauf

  2. Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia

    Abdullah S. M. Aljohani

  3. Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia

    Fahad A. Alhumaydhi

  4. Department of Biotechnology, Woman University, Mardan, Mardan KPK, Pakistan

    Saima Naz

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  1. Abdur Rauf
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  2. Abdullah S. M. Aljohani
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  3. Fahad A. Alhumaydhi
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  4. Saima Naz
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Correspondence to Abdur Rauf.

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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2020, pp. 867–869.

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Rauf, A., Aljohani, A.S.M., Alhumaydhi, F.A. et al. A Novel Compound from the Bark of Diospyros lotus and their Urease Inhibitory Activity. Chem Nat Compd 56, 1005–1007 (2020). https://doi.org/10.1007/s10600-020-03214-9

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  • DOI: https://doi.org/10.1007/s10600-020-03214-9

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