Two new alkaloids, 3-(hydroxymethyl)-6,9-dimethyl-7H-benzo[de]quinolin-7-one (1) and 3-(hydroxymethyl)-8-methoxy-6,9-dimethyl-7H-benzo[de]quinolin-7-one (2), together with two known alkaloids (3 and 4) were isolated from the seeds of Cassia alata. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–4 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results revealed that compounds 1–4 have potential anti-TMV activity with inhibition rates of 29.2, 38.5, 24.2, and 28.8% at the concentration of 20 μM, respectively. The inhibition rates of 1 and 2 are higher than that of the postive control.
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Acknowledgment
This project was supported by the National Natural Science Foundation of China (Nos. 21302164, 31460144, 21562044, and 21262048) and the Program for Innovative Research Team (in Science and Technology) in University of Yunnan Province (No. IRTSTYN 2014-11).
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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2017, pp. 957–959.
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Yang, Y., Shang, SZ., Zhao, W. et al. Two New Alkaloids from the Seeds of Cassia alata and Their Anti-Tobacco Mosaic Virus Activity. Chem Nat Compd 53, 1127–1130 (2017). https://doi.org/10.1007/s10600-017-2215-9
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DOI: https://doi.org/10.1007/s10600-017-2215-9