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Lipase-Catalysed Addition of Pyrrolidine to Chalcone and Benzylidene Malonate Derivatives

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Chemistry of Natural Compounds Aims and scope

The porcine pancreas lipase (PPL) type II catalyzes the aminolysis of benzylidene malonates by regiospecific amidation of substrates and afforded the Z-isomer; no E-isomer or diamide byproducts were observed. PPL also catalyzes Michael addition of acetophenone to various derivatives of chalcones.

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Acknowledgment

This work was supported by the Research Council of Shahid Beheshti University Tehran, Iran for which the authors are thankful.

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Authors and Affiliations

  1. Department of Pure Chemistry, Faculty of Chemistry, Shahid Beheshti University, G. C., Tehran, Iran

    Z. Habibi, R. Kheyrabadi, M. Moemeni & S. Nazari

  2. Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

    M. Yousefi

  3. National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran

    M. Mohammadi

Authors
  1. Z. Habibi
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  2. M. Yousefi
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  3. R. Kheyrabadi
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  4. M. Mohammadi
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  5. M. Moemeni
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  6. S. Nazari
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Corresponding author

Correspondence to Z. Habibi.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2015, pp. 740–742.

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Habibi, Z., Yousefi, M., Kheyrabadi, R. et al. Lipase-Catalysed Addition of Pyrrolidine to Chalcone and Benzylidene Malonate Derivatives. Chem Nat Compd 51, 861–864 (2015). https://doi.org/10.1007/s10600-015-1434-1

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  • DOI: https://doi.org/10.1007/s10600-015-1434-1

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