Abstract
Ferroptosis is a type of regulated cell death that plays an essential role in various brain diseases, including cranial trauma, neuronal diseases, and brain tumors. It has been reported that cancer cells rely on their robust antioxidant capacity to escape ferroptosis. Therefore, ferroptosis exploitation could be an effective strategy to prevent tumor proliferation and invasion. Glioma is a common malignant craniocerebral tumor exhibiting complicated drug resistance and survival mechanisms, resulting in a high mortality rate and short survival time. Recent studies have determined that metabolic alterations in glioma offer exploitable therapeutic targets. These metabolic alterations allow targeted therapy to achieve some initial efficacy but have failed to inhibit glioma growth, invasion, and drug resistance effectively. It has been proposed that the reason for the high malignancy and drug resistance observed with glioma is that these tumors can effectively evade ferroptosis. Ferroptosis-inducing drugs were found to exert a positive effect by targeting this particular characteristic of glioma cells. Moreover, gliomas develop enhanced drug resistance through anti-ferroptosis mechanisms. In this study, we provided an overview of the mechanisms by which glioma aggressiveness and drug resistance are mediated by the evasion of ferroptosis. This information might provide new targets for glioma therapy as well as new insights and ideas for future research.
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This study was funded by the Department of Science and Technology of Jilin Province (20180101136JC), Department of Finance of Jilin Province (2018SCZ030), the Education Department of Jilin Province (JJKH20190005KJ), Development and Reform Commission Engineering Laboratory Project of Jilin Province (2019C031), the Norman Bethune Program of Jilin University (2015218), the Lateral Research Funds of Jilin University (2015377), Excellent Talents Training Plan of China-Japan Union Hospital (YXZN-201803), the Special Project for Health Research Talents of Jilin Province.
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Renxuan Huang developed the concept for the article and prepared the original draft. Rui Dong, Nan Wang, Yichun He, Peining Zhu, Chong Wang, and Beiwu Lan performed the literature search and data analysis. Liankun Sun critically revised the work. Funding acquisition and project administration were carried out by Yufei Gao. All authors read and approved the final manuscript.
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Huang, R., Dong, R., Wang, N. et al. Adaptive Changes Allow Targeting of Ferroptosis for Glioma Treatment. Cell Mol Neurobiol 42, 2055–2074 (2022). https://doi.org/10.1007/s10571-021-01092-5
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DOI: https://doi.org/10.1007/s10571-021-01092-5