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Association of serum uric acid levels with SYNTAX score II and long term mortality in the patients with stable angina pectoris who undergo percutaneous coronary interventions due to multivessel and/or unprotected left main disease

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Abstract

Serum uric acid (SUA) level was shown in various studies to be related to the presence of coronary artery disease and subsequent cardiovascular events. The aim of the present study was to evaluate the association of SUA with SYNTAX score II (SSII) and the long-term prognosis of patients with stable angina pectoris who underwent percutaneous revascularization due to multivessel disease (MVD) and/or unprotected left main disease (UPLMD). Two-hundred and ninety patients with MVD and/or UPLMD who were treated consecutively with percutaneous coronary intervention (PCI) were included in the present study. The study population was divided into high SSII (n: 145; SSII > 32.9) and low SSII (n: 145; SSII ≤ 32.9) according to the median SSII value. The SUA value was significantly higher in the high SSII group than in the low SSII group (5.53 ± 1.95 vs. 6.07 ± 1.88; p = 0.001) and was found to be an independent predictor of high SSII (OR 1.306; 95% CI 1.119–1.525; p = 0,001). Twenty-eight patients (9.7%) died during the long-term follow-up, and SUA and SSII were additionally found to be independent predictors of long-term mortality (HR 1.245, 95% CI 1.046–1.482, p = 0.014; HR 1.042, 95% CI 1.007–1.079, p = 0.018, respectively). In the present study, SUA level was demonstrated to be associated with high SSII and long-term mortality in patients with MVD and/or UPLMD who were treated with PCI.

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Acknowledgements

The authors thank http://www.metastata.com for their contributions to the statistical analysis and trial design.

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Authors and Affiliations

  1. Department of Cardiology, Kafkas University Medical Faculty, Kars, Turkey

    Yavuz Karabağ, Ibrahim Rencuzogullari, Metin Çağdaş & Süleyman Karakoyun

  2. Department of Cardiology, Kars Harakani State Hospital, Kars, Turkey

    Mahmut Yesin

  3. Department of Internal Medicine, Kafkas University Medical Faculty, Kars, Turkey

    Eray Atalay & Öznur Sadioglu Çağdaş

  4. Department of Cardiology, Gaziemir State Hospital, Izmir, Turkey

    Mustafa Ozan Gürsoy

  5. Department of Cardiology, Midyat State Hospital, Mardin, Turkey

    Cengiz Burak

  6. Department of Cardiology, Ataturk University Medical Faculty, Erzurum, Turkey

    Halil Ibrahim Tanboğa

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  1. Yavuz Karabağ
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  2. Ibrahim Rencuzogullari
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  3. Metin Çağdaş
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  4. Süleyman Karakoyun
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Correspondence to Yavuz Karabağ.

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Karabağ, Y., Rencuzogullari, I., Çağdaş, M. et al. Association of serum uric acid levels with SYNTAX score II and long term mortality in the patients with stable angina pectoris who undergo percutaneous coronary interventions due to multivessel and/or unprotected left main disease. Int J Cardiovasc Imaging 35, 1–7 (2019). https://doi.org/10.1007/s10554-018-1446-6

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  • DOI: https://doi.org/10.1007/s10554-018-1446-6

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