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Research progress of ferroptosis and inflammatory bowel disease

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A Correction to this article was published on 24 May 2024

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Abstract

Inflammatory bowel disease (IBD) is a non-specific chronic inflammatory disorder of the gastrointestinal tract, imposing significant burdens on both society and individuals. As a new type of regulated cell death (RCD), ferroptosis is different from classic RCDs such as apoptosis and necrosis in cell morphology, biochemistry and genetics. The main molecular mechanisms of ferroptosis include dysregulation of iron metabolism, impaired antioxidant capacity, mitochondrial dysfunction, accumulation of lipid-associated super-oxides, and membrane disruption. In recent years, increasing evidence has shown that ferroptosis is involved in the pathophysiology of inflammatory bowel disease. However, the exact roles and underlying molecular mechanisms have not been fully elucidated. This article reviews the mechanism of ferroptosis in the occurrence and development of inflammatory bowel disease, in order to provide new ideas for the pathophysiological research of inflammatory bowel disease. Additionally, we discuss potential strategies for the prevention and treatment of inflammatory bowel disease by targeting ferroptosis.

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Funding

This study was financially supported by grants from the National Natural Science Foundation of China (81803800), the Natural Science Foundation of Chongqing, China (cstc2018jcyjAX0529 and CSTB2023NSCQ-MSX0469).

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  1. College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China

    Baolian Ma, Xiaoxue Hu, Xiaowen Ai & Yonglan Zhang

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  1. Baolian Ma
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  2. Xiaoxue Hu
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  3. Xiaowen Ai
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  4. Yonglan Zhang
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H and A conducted a data search and M wrote the main manuscript text and Z provided the funding. All authors reviewed the manuscript.

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Correspondence to Yonglan Zhang.

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Ma, B., Hu, X., Ai, X. et al. Research progress of ferroptosis and inflammatory bowel disease. Biometals (2024). https://doi.org/10.1007/s10534-024-00604-2

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