Abstract
Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Tectochrysin is a flavonoid compound and rich in a traditional Chinese Medicine Alpinia oxyphylla Miq., which has antioxidant, anti-inflammatory, anti-cancer, anti-bacterial, anti-diarrhea, hepatoprotective, and neuro-protective effects. Therefore, we tested if tectochrysin had an effect on aging in Caenorhabditis elegans (C. elegans). Our results showed that tectochrysin could extend the lifespan of C. elegans by up to 21.0%, delay the age-related decline of body movement, improve high temperature-stress resistance and anti-infection capacity, and protected worms against Aβ1-42-induced toxicity. Tectochrysin could not extend the lifespan of the mutants from genes daf-2, daf-16, eat-2, aak-2, skn-1, and hsf-1. Tectochrysin could increase the expression of DAF-16 regulated genes. The extension of lifespan by tectochrysin requires FOXO/DAF-16 and HSF-1. Overall, our findings suggest that tectochrysin may have a potential effect on extending lifespan and age-related diseases.
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Acknowledgements
We thank the Caenorhabditis Genetic Center (CGC) for providing the worm strains, which is funded by NIH Office of Research Infrastructure Program (P40OD010440). Financial supports were received from the Natural Science Foundation of China (Grant Nos. 81771516 and 81671405) and the Science and Technology Cooperation Project of Luzhou and Southwest Medical University (2016LZXNYD-Z05).
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The study was conceived and designed by H.-R.L and G.-S.W. Material preparation, data collection and analysis were performed by M.L., L.T. Q.Z., and Z.-L.Y. The first draft of the manuscript was written by M.L, and then the manuscript was revised by J.-N.C., X.-G.Z., H.-R.L and G.-S.W. All authors commented on previous versions of the manuscript. All the authors have read and approved the final version.
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Lu, M., Tan, L., Zhou, XG. et al. Tectochrysin increases stress resistance and extends the lifespan of Caenorhabditis elegans via FOXO/DAF-16. Biogerontology 21, 669–682 (2020). https://doi.org/10.1007/s10522-020-09884-w
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DOI: https://doi.org/10.1007/s10522-020-09884-w