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Longevity and anti-aging effects of curcumin supplementation

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Abstract

Aging is a gradual and irreversible process that is accompanied by an overall decline in cellular function and a significant increase in the risk of age-associated disorders. Generally, delaying aging is a more effective method than treating diseases associated with aging. Currently, researchers are focused on natural compounds and their therapeutic and health benefits. Curcumin is the main active substance that is present in turmeric, a spice that is made up of the roots and rhizomes of the Curcuma longa plant. Curcumin demonstrated a positive impact on slowing down the aging process by postponing age-related changes. This compound may have anti-aging properties by changing levels of proteins involved in the aging process, such as sirtuins and AMPK, and inhibiting pro-aging proteins, such as NF-κB and mTOR. In clinical research, this herbal compound has been extensively examined in terms of safety, efficacy, and pharmacokinetics. There are numerous effects of curcumin on mechanisms related to aging and human diseases, so we discuss many of them in detail in this review.

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Acknowledgements

Our sincere gratitude goes to authors who contributed their time and expertise to accomplish this article.

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Authors and Affiliations

  1. Department of Infectious and Tropical Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Mehran Izadi

  2. Synapse Laboratory Diagnostic Technologies Accelerator, Tehran, Iran

    Mehran Izadi, Nariman Sadri, Amirhossein Abdi, Mohammad Mahdi Raeis Zadeh, Dorsa jalaei, Mohammad Mahdi Ghazimoradi, Sara Shouri & Safa Tahmasebi

  3. Department of Research & Technology, Zeenome Longevity Research Institute, Tehran, Iran

    Mehran Izadi, Nariman Sadri, Amirhossein Abdi, Mohammad Mahdi Raeis Zadeh, Dorsa jalaei, Mohammad Mahdi Ghazimoradi, Sara Shouri & Safa Tahmasebi

  4. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Nariman Sadri

  5. School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Amirhossein Abdi, Mohammad Mahdi Raeis Zadeh, Mohammad Mahdi Ghazimoradi & Sara Shouri

  6. School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran

    Dorsa jalaei

  7. Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Safa Tahmasebi

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  1. Mehran Izadi
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Contributions

Mehran Izadi, Nariman Sadri, Amirhossein Abdi, and Mohammad Mahdi Raeis Zadeh contributed to hypothesis, data gathering, and writing the main text of the manuscript. Dorsa Jalali, Mohammad Mahdi Ghazimoradi, and Sara Shouri contributed to hypothesis, data gathering, designing figure and tables, and final editing. Safa Tahmasebi contributed to the writing, scientific and structural editing, hypothesis, correspondence, and verifying the manuscript before submission.

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Izadi, M., Sadri, N., Abdi, A. et al. Longevity and anti-aging effects of curcumin supplementation. GeroScience 46, 2933–2950 (2024). https://doi.org/10.1007/s11357-024-01092-5

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