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Effect of Rat Exposure to Moderate Pressure Oxygen Atmosphere on Resistance of Erythrocytes against Hemolysis

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Bulletin of Experimental Biology and Medicine Aims and scope

Exposure of male Wistar rats to oxygen atmosphere at moderate pressure (1.10-1.15 atm) for 4 h resulted in significant, transient, and reversible decrease in hemolytic resistance of peripheral blood erythrocytes. In 2 days after oxygen exposure, the bone marrow released young erythrocytes with enhanced hemolytic resistance as a compensation for oxygen injury. These findings suggest that normobaric oxygen load can be viewed as a stress factor of moderate intensity.

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Authors and Affiliations

  1. A. F. Tsyb Medical Radiological Research Center, Affiliated Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Obninsk, Russia

    O. S. Izmest’eva, L. A. Dzikovskaya & L. P. Zhavoronkov

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  1. O. S. Izmest’eva
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  2. L. A. Dzikovskaya
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  3. L. P. Zhavoronkov
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Correspondence to O. S. Izmest’eva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 2, pp. 156-160, February, 2020

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Izmest’eva, O.S., Dzikovskaya, L.A. & Zhavoronkov, L.P. Effect of Rat Exposure to Moderate Pressure Oxygen Atmosphere on Resistance of Erythrocytes against Hemolysis. Bull Exp Biol Med 169, 201–204 (2020). https://doi.org/10.1007/s10517-020-04850-5

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  • DOI: https://doi.org/10.1007/s10517-020-04850-5

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