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Effects of Exposure of Animals to Oxygen Atmosphere at Low Pressure on Lipid Peroxidation and Antioxidant Defense

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Relatively short-term (2.5 or 5 h) exposure of Wistar rats to oxygen atmosphere at moderate pressure (1.10-1.15 atm) resulted in an increase in LPO level and reduction of antioxidant activity in the blood serum. An increase in malondialdehyde concentration 1 day after termination of the exposure was followed by a decrease in the inhibiting activity of free radical oxidation of liposomal phospholipids induced by Fe(II) ions (100 μm). Malondialdehyde concentration increased by 1.29 times already after 2.5-h exposure and did not changed when the duration of the exposure to oxygen atmosphere was prolonged to 5 h. These data confirm the necessity of using substances potentiating antioxidant defense of the body during exposure to normobaric oxygenation.

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Authors and Affiliations

  1. A. F. Tsyb Medical Radiological Research Center, Affiliated Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Obninsk, Russia

    N. I. Ryabchenko, L. A. Dzikovskaya, O. S. Izmest’eva & L. P. Zhavoronkov

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  1. N. I. Ryabchenko
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  2. L. A. Dzikovskaya
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  3. O. S. Izmest’eva
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  4. L. P. Zhavoronkov
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Correspondence to O. S. Izmest’eva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 5, pp. 583-586, May, 2018

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Ryabchenko, N.I., Dzikovskaya, L.A., Izmest’eva, O.S. et al. Effects of Exposure of Animals to Oxygen Atmosphere at Low Pressure on Lipid Peroxidation and Antioxidant Defense. Bull Exp Biol Med 165, 640–643 (2018). https://doi.org/10.1007/s10517-018-4231-6

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  • DOI: https://doi.org/10.1007/s10517-018-4231-6

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