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Peculiarities of Pharmacokinetics and Bioavailability of Some Cardiovascular Drugs under Conditions of Antiorthostatic Hypokinesia

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We studied pharmacokinetics and bioavailability of verapamil, propranolol, and ethacizine in healthy volunteers after single oral administration under normal conditions and on the second day of simulated antiorthostatic hypokinesia modeling some effects of microgravity. Under conditions of antiorthostatic hypokinesia, a tendency to a decrease in half-elimination period, mean retention time, and volume of distribution and an increase in the rate of absorption, ratio of maximum concentrations, and relative rate of absorption of verapamil and propranolol were revealed. For ethacizine, a statistically significant increase in the time of attaining maximum concentration and volume of distribution and a decrease in the maximum concentration, rate of absorption, ratio of maximum concentrations, and relative rate of absorption under conditions of antiorthostatic hypokinesia were found.

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Authors and Affiliations

  1. Laboratory for Development of Means and Methods of Providing Medical Care under Extreme Conditions and Telemedicine, State Research Center Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

    A. V. Polyakov, I. V. Kovachevich & L. G. Repenkova

  2. Department of Clinical Pharmacology and Propaedeutic of Internal Diseases, I. M. Sechenov First Moscow State Medical University, the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

    A. A. Svistunov, S. N. Kondratenko & V. G. Kukes

  3. Department of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, Moscow, Russia

    M. I. Savelyeva

Authors
  1. A. V. Polyakov
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  2. A. A. Svistunov
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  3. S. N. Kondratenko
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  4. I. V. Kovachevich
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  5. L. G. Repenkova
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  6. M. I. Savelyeva
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  7. V. G. Kukes
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Corresponding author

Correspondence to S. N. Kondratenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 10, pp. 449-453, October, 2019

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Polyakov, A.V., Svistunov, A.A., Kondratenko, S.N. et al. Peculiarities of Pharmacokinetics and Bioavailability of Some Cardiovascular Drugs under Conditions of Antiorthostatic Hypokinesia. Bull Exp Biol Med 168, 465–469 (2020). https://doi.org/10.1007/s10517-020-04732-w

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  • DOI: https://doi.org/10.1007/s10517-020-04732-w

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