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Evaluation of the Possibility of Correction of Doxorubicin-Induced Chronic Heart Failure in the Experiment with 3-Hydroxypyridine Acetylcysteinate and 3-Hydroxypyridine Succinate

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Bulletin of Experimental Biology and Medicine Aims and scope

The possibility of correction of morphological changes in the myocardium and biochemical parameters of the blood with 3-hydroxypyridine acetylcysteinate in a dose of 25 mg/kg was studied in the model of doxorubicin-induced chronic heart failure in rats. It was found that 3-hydroxypyridine acetylcysteinate in a dose of 25 mg/kg produced less pronounced cardio-protective effect in experimental chronic heart failure than 3-hydroxypyridine succinate.

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Authors and Affiliations

  1. N. P. Ogarev Mordovian National Research State University, Saransk, Republic of Mordovia, Russia

    M. N. Zamotaeva, V. I. Inchina, V. V. Konorev & N. D. Kuz’michev

  2. N. M. Emanuel Institute of Biochemical Physics, Moscow, Russia

    Yu. V. Kuznetsov

Authors
  1. M. N. Zamotaeva
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  2. V. I. Inchina
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  3. V. V. Konorev
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  4. Yu. V. Kuznetsov
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  5. N. D. Kuz’michev
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Corresponding author

Correspondence to V. V. Konorev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 3, pp. 317-320, March, 2018

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Zamotaeva, M.N., Inchina, V.I., Konorev, V.V. et al. Evaluation of the Possibility of Correction of Doxorubicin-Induced Chronic Heart Failure in the Experiment with 3-Hydroxypyridine Acetylcysteinate and 3-Hydroxypyridine Succinate. Bull Exp Biol Med 165, 344–346 (2018). https://doi.org/10.1007/s10517-018-4166-y

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  • DOI: https://doi.org/10.1007/s10517-018-4166-y

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