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Quantitative Ultrasound for Nondestructive Characterization of Engineered Tissues and Biomaterials

  • Nondestructive Characterization of Biomaterials for Tissue Engineering and Drug Delivery
  • Published:
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Abstract

Non-invasive, non-destructive technologies for imaging and quantitatively monitoring the development of artificial tissues are critical for the advancement of tissue engineering. Current standard techniques for evaluating engineered tissues, including histology, biochemical assays and mechanical testing, are destructive approaches. Ultrasound is emerging as a valuable tool for imaging and quantitatively monitoring the properties of engineered tissues and biomaterials longitudinally during fabrication and post-implantation. Ultrasound techniques are rapid, non-invasive, non-destructive and can be easily integrated into sterile environments necessary for tissue engineering. Furthermore, high-frequency quantitative ultrasound techniques can enable volumetric characterization of the structural, biological, and mechanical properties of engineered tissues during fabrication and post-implantation. This review provides an overview of ultrasound imaging, quantitative ultrasound techniques, and elastography, with representative examples of applications of these ultrasound-based techniques to the field of tissue engineering.

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Acknowledgments

This work was supported, in part, by a grant from the National Institutes of Health (R01 EB018210).

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of Rochester, 310 Goergen Hall, P.O. Box 270168, Rochester, NY, 14627, USA

    Diane Dalecki

  2. Department of Internal Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267, USA

    Karla P. Mercado

  3. Department of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Box 711, Rochester, NY, 14642, USA

    Denise C. Hocking

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  1. Diane Dalecki
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Correspondence to Diane Dalecki.

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Associate Editor Agata Exner oversaw the review of this article.

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Dalecki, D., Mercado, K.P. & Hocking, D.C. Quantitative Ultrasound for Nondestructive Characterization of Engineered Tissues and Biomaterials. Ann Biomed Eng 44, 636–648 (2016). https://doi.org/10.1007/s10439-015-1515-0

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