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Decreased SOCS1 mRNA expression levels in peripheral blood mononuclear cells from patients with systemic lupus erythematosus in a Chinese population

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Abstract

The aim of this study was to investigate the mRNA expression levels of suppressor of cytokine signaling 1 (SOCS1) in patients with systemic lupus erythematosus (SLE) compared with healthy controls. The associations of systemic lupus erythematosus disease activity index scores and clinical features of SLE with the expression levels of SOCS1 mRNA were also evaluated. Real-time quantitative reverse transcription-polymerase chain reaction was applied to detect the mRNA expression levels of SOCS1 in peripheral blood mononuclear cells from 34 patients with SLE and 34 healthy controls. The mRNA expression level of SOCS1 was significantly decreased in SLE patients in comparison with healthy controls (Z = −4.207, P < 0.001). Lower SOCS1 mRNA expression was detected in active SLE patients when compared with inactive ones (Z = −2.428, P = 0.015). There was no significant difference found for the SOCS1 mRNA levels between SLE patients with nephritis and those without (Z = −0.642, P = 0.521). The presence of photosensitivity, proteinuria, positive antinuclear antibody, and C4 decline were associated with SOCS1 mRNA levels in SLE patients (all P < 0.05). Furthermore, the SOCS1 mRNA expression was negatively correlated with disease activity (r s  = −0.372, P = 0.030). Our results suggest that the dysregulation of SOCS1 might be associated with the pathogenesis of SLE.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (81172764).

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People’s Republic of China

    Li-Juan Qiu, Yan Liang, Han Cen, Min Zhang, Peng-Fei Wen, Jing Ni, Wang-Dong Xu, Rui-Xue Leng, Hai-Feng Pan & Dong-Qing Ye

  2. Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People’s Republic of China

    Li-Juan Qiu, Yan Liang, Han Cen, Min Zhang, Peng-Fei Wen, Jing Ni, Wang-Dong Xu, Rui-Xue Leng, Hai-Feng Pan & Dong-Qing Ye

  3. Division of Chronic Infectious Disease Prevention and Control, Nanjing Municipal Center for Disease Control and Prevention, 3 Zizhulin, Nanjing, 210003, Jiangsu, People’s Republic of China

    Ke Xu

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  1. Li-Juan Qiu
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  2. Ke Xu
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Correspondence to Dong-Qing Ye.

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Li-Juan Qiu, Ke Xu and Yan Liang contributed equally to this work and should be considered co-first authors.

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Qiu, LJ., Xu, K., Liang, Y. et al. Decreased SOCS1 mRNA expression levels in peripheral blood mononuclear cells from patients with systemic lupus erythematosus in a Chinese population. Clin Exp Med 15, 261–267 (2015). https://doi.org/10.1007/s10238-014-0309-2

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  • DOI: https://doi.org/10.1007/s10238-014-0309-2

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