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A nonrandomized controlled trial: long-term outcomes of LATG/LAPG for cStage I gastric cancer: Japan Clinical Oncology Group Study JCOG1401

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Abstract

Background

A previous report confirmed the safety of laparoscopy-assisted total and proximal gastrectomies (LATG and LAPG) (JCOG1401). This report demonstrates the 5-year relapse-free survival (RFS) and overall survival (OS) after long-term follow-up to confirm the efficacy of these surgical methods as key secondary endpoints for cStage I gastric cancer.

Methods

This study enrolled patients who had histologically proven gastric adenocarcinoma and were diagnosed with clinical T1N0, T1N(+), or T2N0 tumors according to the 14th edition of the Japanese Classification of Gastric Carcinoma (3rd English edition).

Results

Between April 2015 and February 2017, 246 patients were enrolled, although one patient was excluded because of misregistration. Meticulous follow-up was continued for > 5 years for each patient, and the data were analyzed in March 2022. The 5-year RFS was 90.0% (95% confidence interval [CI] 85.5–93.2%), and the 5-year OS was 91.2% (95% CI 86.9–94.2%) in all enrolled patients. Grade 3 or 4 late postoperative complications were detected in 12.7% of patients.

Conclusions

This single-arm study showed that the long-term outcomes of LATG/LAPG for cStage I gastric cancer were acceptable, which is considered one of the standard treatments when performed by experienced surgeons.

Trail registration UMIN000017155 (http://www.umin.ac.jp/ctr/).

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Funding

This study was supported in part by the National Cancer Center Research and Development Funds (26-A-4, 29-A-3,2020-J-3, 2023-J-03), Grant-in-Aid for Clinical Cancer Research H26-053, and AMED under Grant numbers JP18ck0106317 and JP15ck0106056.

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Authors and Affiliations

  1. Department of Surgery, Gastroenterological Center, Yokohama City University, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan

    Chikara Kunisaki

  2. Department of Gastrointestinal Surgery, Tachikawa Hospital, Tachikawa, Japan

    Hitoshi Katai

  3. Department of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan

    Hitoshi Katai & Takaki Yoshikawa

  4. Department of Gastroenterological Surgery, Saitama Medical University, Saitama, Japan

    Shinichi Sakuramoto

  5. Japan Clinical Oncology Group Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan

    Junki Mizusawa & Hiroshi Katayama

  6. Department of Gastroenterological Surgery, Ishikawa Prefectural Central Hospital, Kanazawa, Japan

    Shinichi Kadoya

  7. Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan

    Takanobu Yamada

  8. Department of Gastric Surgery, National Cancer Center Hospital East, Kashiwa, Japan

    Takahiro Kinoshita

  9. Division of Gastric Surgery, Shizuoka Cancer Center, Nagaizumi, Japan

    Masanori Terashima

Authors
  1. Chikara Kunisaki
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  2. Hitoshi Katai
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  3. Shinichi Sakuramoto
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  4. Junki Mizusawa
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  5. Hiroshi Katayama
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Consortia

the Stomach Cancer Study Group of Japan Clinical Oncology Group

Corresponding author

Correspondence to Chikara Kunisaki.

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All procedures performed in studies involving human participants were in accordance with the clinical standards of the institutional and /or national research committee with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Kunisaki, C., Katai, H., Sakuramoto, S. et al. A nonrandomized controlled trial: long-term outcomes of LATG/LAPG for cStage I gastric cancer: Japan Clinical Oncology Group Study JCOG1401. Gastric Cancer 27, 164–175 (2024). https://doi.org/10.1007/s10120-023-01432-y

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