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Epidemiology and mortality of candidemia both related and unrelated to the central venous catheter: a retrospective cohort study

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Abstract

Our objective was to compare mortality, epidemiology, and morbidity in hospitalized patients with candidemia which was both related and unrelated to the central venous catheter (CVC). This was a monocentric, retrospective cohort study of candidemia. The sample consisted of 103 patients with laboratory-confirmed nosocomial candidemia hospitalized between 2006 and 2013 in a tertiary care public hospital. We included 65 (63.1 %) patients (24 in the CVC-positive group, 41 in the CVC-negative group). Demographic data and risk factors were recorded using a structured case report form. In the group of candidemia associated to the CVC, survival at day 50 was 58.6 ± 11.9 %, compared to 26.5 ± 8.9 % for the CVC-negative group (p-value = 0.012); the hazard ratio of death was 0.38 (95 % confidence interval 0.17–0.85, p-value = 0.019). Compared with the CVC-positive patients, CVC-negative patients were often colonized with yeast (41.5 % vs. 16.7 %, p-value = 0.041), had a shorter previous in-hospital stay (20 days vs. 34 days, p-value = 0.023), and were more severely ill (severe sepsis 85.4 % vs. 58.3 %, p-value = 0.016). In this study, when the origin of candidemia was not the CVC, patients were more seriously ill, had a higher mortality rate, and the removal of the catheter seemed to lead to disappointing results. It would be useful to explore the impact of retention of the CVC on survival in the CVC-negative patients, where the CVCs are essential to treating these patients.

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Acknowledgments

We thank all those who helped us in this study; in particular, the Infectious Diseases Department and the Microbiology Department for making this study possible.

We thank Mr. Cathal Mac Gabhann for checking the English version of the manuscript.

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Authors and Affiliations

  1. Public Health Department, Hôpital Brugmann, Infectious Diseases Department, Université Libre de Bruxelles, 4 place A Van Gehuchten, 1020, Brussels, Belgium

    S. Arias

  2. Hôpital Erasme, Microbiology Department, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium

    O. Denis & I. Montesinos

  3. Internal Medicine Department, Centre Hospitalier Universitaire de Charleroi, Hôpital Civil Marie Curie, 140 Chaussée de Bruxelles, 6042, Lodelinsart, Belgium

    S. Cherifi

  4. Microbiology Department LHUB-ULB, Laboratoire Hospitalier Universitaire de Bruxelles (Brussels Academic Hospital Lab), Université Libre de Bruxelles, 322 rue Haute, 1000, Brussels, Belgium

    V. Y. Miendje Deyi

  5. Infectious Diseases Department, Université Catholique de Louvain, 31 Promenade de l’Alma, 1200, Brussels, Belgium

    F. Zech

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  1. S. Arias
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Correspondence to S. Arias.

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None of the authors report conflicts of interest relevant to this article.

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This work was approved by the ethics committee at Hôpital Brugmann on 15th October 2014.

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Arias, S., Denis, O., Montesinos, I. et al. Epidemiology and mortality of candidemia both related and unrelated to the central venous catheter: a retrospective cohort study. Eur J Clin Microbiol Infect Dis 36, 501–507 (2017). https://doi.org/10.1007/s10096-016-2825-3

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  • DOI: https://doi.org/10.1007/s10096-016-2825-3

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