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Hypoglycemic effect of standardized Chrysanthemum zawadskii ethanol extract in high-fat diet/streptozotocin-induced diabetic mice and rats

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Abstract

Chrysanthemum zawadskii (CZ) is a perennial herb belonging to the Asteraceae family. CZ is used medicinally to treat inflammatory and uterine diseases in Asia. CZ was extracted with 50% ethanol and CZ extract (CZE; at 125, 250, and 500 mg/kg body weight) was administered orally every day for 5 or 6 weeks to investigate the anti-diabetic effects in streptozotocin (STZ)-induced rats and STZ + high-fat diet (HFD)-fed mice. CZE significantly decreased fasting blood glucose levels in STZ- and STZ + HFD-induced diabetic models. In addition, glucose tolerance and insulin tolerance were improved in the STZ + HFD + CZE group by increasing insulin levels and decreasing hemoglobin A1c (HbA1c) levels in serum. Furthermore, CZE supplements decreased components of the serum lipid profile such as triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels. These results suggest that CZE may be a potential candidate for controlling hyperglycemia.

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Acknowledgements

This research was supported by the Ministry of Trade, Industry and Energy (R0004042) of Korea.

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Authors and Affiliations

  1. Food Science R&D Center, KolmarBNH Co., Ltd., Sejong, 30003, Korea

    Yang-Ji Kim, Hyun-Kyu Kim & Hak Sung Lee

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  1. Yang-Ji Kim
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  2. Hyun-Kyu Kim
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Correspondence to Hak Sung Lee.

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Kim, YJ., Kim, HK. & Lee, H.S. Hypoglycemic effect of standardized Chrysanthemum zawadskii ethanol extract in high-fat diet/streptozotocin-induced diabetic mice and rats. Food Sci Biotechnol 27, 1771–1779 (2018). https://doi.org/10.1007/s10068-018-0399-9

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  • DOI: https://doi.org/10.1007/s10068-018-0399-9

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