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Isolation and identification of flavonoids from Gujeolcho (Chrysanthemum zawadskii var. latilobum) as inhibitor of histamine release

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Abstract

In an ongoing search of compounds from natural sources that exhibit anti-allergic properties, 3 flavonoids were isolated from the ethyl acetatefraction of methanol extracts of gujeolcho (Chrysanthemum zawadskii var. latilobum), with guided histamine release inhibitory effects. The isolated compounds were identified as eriodictyol-7-O-β-d-glucuronide, 5,7-dihydroxy-4-chromene, and 6-methoxyluteolin based on spectroscopic evidences including NMR and MS spectra. These results suggest that gujeolcho extracts and 3 compounds would be candidates as therapeutic or preventive agents for allergic reaction.

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Authors and Affiliations

  1. Department of Food Science and Nutrition, Pukyong National University, Busan, 608-737, Korea

    Dae-Seok Byun

  2. Institute of Marine Life Science, Pukyong National University, Busan, 608-737, Korea

    Sun-Yup Shim

  3. Research Center of HC Biotech Co., Ltd., Jangheung, Jeonnam, 529-861, Korea

    Hye-Sook Kang

  4. Subtropical Horticulture Research Institute, Jeju National University, Jeju, 690-756, Korea

    Hyeon-Jin Sun

  5. Department of Marine Food Science & Technology, Chonnam National University, Yeosu, Jeonnam, 550-749, Korea

    Young-Ju Lee

  6. Department of Food and Nutrition, Sunchon National University, Suncheon, Jeonnam, 540-742, Korea

    Jeong-Ro Park & Soon-Sil Chun

  7. Department of Microbiology, Pukyong National University, Busan, 608-737, Korea

    Young-Hwan Song

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  1. Sun-Yup Shim
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  2. Hye-Sook Kang
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  3. Hyeon-Jin Sun
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  4. Young-Ju Lee
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  6. Soon-Sil Chun
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  8. Dae-Seok Byun
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Correspondence to Dae-Seok Byun.

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Shim, SY., Kang, HS., Sun, HJ. et al. Isolation and identification of flavonoids from Gujeolcho (Chrysanthemum zawadskii var. latilobum) as inhibitor of histamine release. Food Sci Biotechnol 21, 613–617 (2012). https://doi.org/10.1007/s10068-012-0079-0

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  • DOI: https://doi.org/10.1007/s10068-012-0079-0

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